Developing new reaction technology for the rapid and efficient construction of therapeutically relevant compounds forms the cornerstone of our research program. Reaction development efforts focus primarily on devising metal-based catalytic protocols for executing stereoselective bond constructions. Our principle objective is the rapid and economical preparation of optically active small-molecule building blocks that relate directly to the complex stereochemical and structural motifs embedded in natural product target molecules.
- Bristol-Myers Squibb Foundation, Award for Synthetic Chemistry (2001)
- Eli Lilly & Co., Award for Synthetic Organic Chemistry (2002)
- Chancellorís Distinguished Research Award (2002)
“Catalytic Asymmetric Aldol Equivalents in the Enantioselective Synthesis of the Apoptolidin C Aglycone,” Vargo TR, Hale JS, Nelson SG Angewandte Chemie-International Edition 2010, 49, 8678-8681
“Catalytic Asymmetric Claisen Rearrangement of Unactivated Allyl Vinyl Ethers,” Geherty ME, Dura RD, Nelson SG Journal of the American Chemical Society 2010, 132, 11875-11877
“Catalytic Asymmetric Synthesis of Complex Polypropionates: Lewis Base Catalyzed Aldol Equivalents in the Synthesis of Erythronolide B,” Chandra B, Fu DZ, Nelson SG ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2010, 49, 2591-2594
“High-Content Analysis of Cancer-Cell-Specific Apoptosis and Inhibition of in Vivo Angiogenesis by Synthetic (-)-Pironetin and Analogs,” Vogt A, McPherson PA, Shen XQ, Balachandran R, Zhu GY, Raccor BS, Nelson SG, Tsang M, Day BW CHEMICAL BIOLOGY & DRUG DESIGN 2009, 74, 358-368
“Automated Image-Based Phenotypic Analysis in Zebrafish Embryos,” Vogt A, Cholewinski A, Shen XQ, Nelson SG, Lazo, JS, Tsang M, Hukriede NA DEVELOPMENTAL DYNAMICS 2009, 238, 656-663
“Pd(II)-catalyzed aliphatic Claisen rearrangements of acyclic allyl vinyl ethers,” Kerrigan NJ, Bungard CJ, Nelson SG TETRAHEDRON 2008, 64, 6863-6869
“[4+2] cycloadditions of N-alkenyl iminium ions: Structurally complex heterocycles from a three-component Diels-Alder reaction sequence,” Sarkar N, Banerjee A, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2008, 130, 9222
“The azido acid approach to beta-peptides: parallel synthesis of a tri-beta-peptide library by fluorous tagging,” Wang X, Nelson SG, Curran DP TETRAHEDRON 2007, 63, 6141-6145
“Stereoselective olefin isomerization leading to asymmetric quaternary carbon construction,” Wang K, Bungard CJ, Nelson SG ORGANIC LETTERS 2007, 9, 2325-2328
“Au(I)-catalyzed annulation of enantioenriched allenes in the enantioselective total synthesis of (-)-rhazinilam,” Liu ZS, Wasmuth AS, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2006, 128, 10352-10353
“Strategies for expanding structural diversity available from olefin isomerization - Claisen rearrangement reactions,” Stevens BD, Bungard CJ, Nelson SG JOURNAL OF ORGANIC CHEMISTRY 2006, 71, 6397-6402
“Catalytic asymmetric assembly of stereodefined propionate units: An enantioselective total synthesis of (-)-pironetin,” Shen XQ, Wasmuth AS, Zhao JP, Zhu C, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2006, 128, 7438-7439
