Peter Wipf | Department of Chemistry

The Wipf Group is currently accepting new graduate students. Apply here.

Total Synthesis of Natural Products; Strain-Release and Heterocyclic Chemistry; Medicinal Chemistry

Total Synthesis of Natural Products

Total Synthesis encompasses all aspects of organic chemistry: The development of new methodology, mechanistic and physical organic experiments, conformational and configurational analysis by spectroscopic and computational methods, and bioorganic and medicinal chemistry. Total Synthesis is also one of the broadest and most rewarding educational experiences for aspiring synthetic chemists.

Strain Release Chemistry

The release of molecular strain energy as a driving force in chemical transformations, often referred to as “strain-release” reactions, has led to unprecedented chemical transformations that provide access to novel scaffolds of interest to medicinal and material chemists. Our group has pioneered the chemistry of bicyclo[1.1.0]butanes (BCBs), one of the most strained (60-68 kcal/mol) carbocycles.

Heterocyclic Chemistry

More than half of all known organic compounds, and the vast majority of drugs, are heterocyclic. We are interested in the development of new stereoselective methods for the preparation of highly functionalized heterocycles. In particular, we have developed novel protocols for indole and five-membered heterocycle synthesis that have been widely adopted in industry and academe.

Medicinal Chemistry

We apply drug discovery and process chemistry methods for the structure-activity analysis of bioactive natural products and the preparation and scale-up of designed molecules. Specifically, we are involved in collaborative translational research with the goal of moving compounds into Phase I clinical trials. Some of these projects, such as flow and photo-flow synthesis and 3D printing, take advantage of the infrastructure of the Combinatorial Chemistry Center (CCC).

Scientific graphic

Computational Prediction of Macroscopic Properties

We are actively engaged in the computational assignment of the relative and absolute stereochemistry of organic molecules and the theoretical prediction of chiroptical phenomena and molecular and macroscopic properties, including structural features relevant for strain-release chemistry.

Awards

Fellow of the National Academy of Inventors (2024)
External Advisory Committee, Purdue Institute for Cancer Research (PICR), West Lafayette, IN (2024-)
ACS Award for Creative Work in Synthetic Organic Chemistry (2023)
Vice President, Organic Syntheses, Inc. (2021-present)
Stanford University Ranking in Top 0.04% of Scientists in the World (2020)
Visiting Professor, RWTH Aachen, Aachen, Germany (2016)
Chair of the Section on Pharmaceutical Sciences of the American Association for the Advancement of Science (2016)
Provost's Award for Excellence in Mentoring (2015)
Humboldt Research Award of the Alexander von Humboldt Foundation (2014)
Harry and Carol Mosher Award of the Santa Clara Valley Section of the ACS (2013)
Edward W. Morley Award of the Cleveland Section of the ACS (2013) 
ACS Pittsburgh Award (2012) 
Fellow of the American Chemical Society (2010) 
Ernest Guenther Award in the Chemistry of Natural Products (2009) 
Associate Editor, ACS Medicinal Chemistry Letters (2009-2022) 
Organic Reactions, Inc. Board of Directors (2007-2023) 
Chancellor's Distinguished Research Award (2008) 
Faculty of 1000 Biology (2006-2011) 
Novartis Chemistry Lectureship (2005) 
Fellow of the Royal Society of Chemistry (FRSC, 2004) 
Visiting Professor (Professeur Associé), École Supérieur de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), Paris, France (September 2004)
Long Range Planning Committee, ACS Division of Medicinal Chemistry (2004-2006)
ISHC Katritzky Award in Heterocyclic Chemistry (2003) 
Fellow of the American Association for the Advancement of Science (AAAS, 2002)
Chair, Gordon Research Conference on Stereochemistry, Salve Regina University, Newport, Rhode Island (June 9-14, 2002)
Visiting Professor (Professeur Associé), Université de Paris-Sud, Orsay, France (November 2001)
Member-at-Large, Organic Division Executive Committee of the ACS (2001-2003)
Novartis Research Award (2000, 2001)
Japan Society for the Promotion of Science Fellow (2000) 
Akron Section ACS Award (1998) 
Arthur C. Cope Scholar Award (1998) 
NIH Medicinal Chemistry Study Section, Member, 1998-2003, Chairman, 2001-2003 
Chancellorís Distinguished Research Award (1997) 
Phi Eta Sigma, Honorary Member (1996) 
Merck Young Investigator Award (1995) 
Zeneca Award for Excellence in Chemistry (1995) 
Camille Dreyfus Teacher-Scholar Award (1995) 
UCI-Allergan Visiting Lecturer, University of California, Irvine, California (1995)
NSF Presidential Faculty Fellow (1994-1999) 
ETH Ruzicka Award (1994) 
Alfred P. Sloan Research Fellow (1994-1996) 
American Cyanamid Faculty Award (1994) 
Eli Lilly Grantee (1993-1995) 
University of Zürich, Distinguished Dissertation Award (1987)

Recent Publications

Click here for a complete list of publications by Distinguished University Professor Peter Wipf

"Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors." Green, N.; LaPorte, M. G.; Paquette, W.; Joyasawal, S.; Mondal, P.; Vaughn, Z.; Carder, E. J.; Liang, M.; Shan, L.; Wang, F.; Tomaino, F.; Srivastava, A.; Flint, A.; Moore, W. J.; Chou, T.-F.; Stott, G. M.; Wolf, M.; Wipf, P.; Huryn, D. M. J. Med. Chem. 2025, 68(14), 14465–14494.

"In Vivo Manipulation of the Protein Homeostasis Network in Rhabdomyosarcoma." Kwong, K.; Pan, Y.; Morales, J.; Watson, M.; Allegakoen, D. V.; Lee, A. G.; Bivona, T. G.; Wipf, P.; Guerriero, C. J.; Brodsky, J. L.; Sabnis, A. J. Oncotarget2025, 16, 681-696.

"Asymmetric Synthesis of Bicyclo[1.1.0]butyl, Azabicyclo[1.1.0]butyl, and Bicyclo[1.1.1]pentyl Sulfoximines using a SuFEx Reaction." Ghantous, P.; Wipf, P. ChemRxiv 2025

"Selective Cycloaddition Reactions of Sulfo-Biginelli Derived 1,2,6-Thiadiazines." Hill, C.; Sambor, M.; Wipf, P. ChemRxiv 2025;

"Mitochondria-Targeted ROS Scavenger JP4-039 Improves Cardiac Function in a Post-Myocardial Infarction Animal Model and Induces Angiogenesis in Vitro." Teixeira, R. B.; Albro, J. H.; Sabra, M.; Abedin, T.; Tucker, A. N.; Sidharth, R.; Sellke, F. W.; Wipf, P.; Abid, M. R. PLoS One 2025, 20(4), e0320703.

"A High Throughput, High Content Screen for Non-Toxic Small Molecules That Reduce Levels of the Nuclear Lamina Protein, Lamin B1." Vollmer, L. L.; Liu, F.; Nmezi, B.; Bey, G. R.; Herdman, N.; Shun, T. Y.; Gough, A.; Liu, R.; Wipf, P.; Lezon, T. R.; Padiath, Q. S.; Vogt, A. Sci. Rep. 2025, 15(1), 7314.

"Assays to Measure Small Molecule Hsp70 Agonist Activity in Vitro and in Vivo." Shapiro, O.; Woods, C.; Gleixner, A. M.; Sannino, S.; Ngo, M.; McDaniels, M. D.; Wipf, P.; Hukriede, N. A.; Donnelly, C. J.; Brodsky, J. L. Anal. Biochem. 2025, 697, 115712.

"JP4-039 Mitigates Cisplatin-Induced Acute Kidney Injury by Inhibiting Oxidative Stress and Blocking Apoptosis and Ferroptosis in Mice." Airik, M.; Clayton, K.; Wipf, P.; Airik, R. Antioxid. 2024, 13(12), 1534.

"Inhibition of ABCG2 Prevents Phototoxicity in a Mouse Model of Erythropoietic Protoporphyria." Zhu, J.; Qin, F.-Y.; Lei, S.; Gu, R.; Qi, Q.; Lu, J.; Anderson, K. E.; Wipf, P.; Ma, X. Nat. Commun. 2024, 15(1), 10557.

"Mechanism of Allosteric Inhibition of Human p97/VCP ATPase and Its Disease Mutant by Triazole Inhibitors." Nandi, P.; DeVore, K.; Wang, F.; Li, S.; Walker, J. D.; Truong, T. T.; LaPorte, M. G.; Wipf, P.; Schlager, H.; McCleerey, J.; Paquette, W.; Columbres, R. C. A.; Gan, T.; Poh, Y.-P.; Fromme, P.; Flint, A. J.; Wolf, M.; Huryn, D. M.; Chou, T.-F.; Chiu, P.-L. Commun. Chem. 2024, 7(1), 177.

"Targeting Axonal Guidance Dependencies in Glioblastoma with ROBO1 CAR T Cells." Chokshi, C. R. et al. Nat. Med. 2024, 30(10), 2936-2946.

"Rhodium(I)-Catalyzed Annulation of Bicyclo[1.1.0]butyl-Substituted Dihydroquinolines and Dihydropyridines." Borgini, M.; Huang, Q.-N.; Chen, P.-P.; Geib, S. J.; Houk, K. N.; Wipf, P. J. Am. Chem. Soc. 2024, 146(22), 14927–14934.

"Synthesis and Biological Analysis of Iso-Dimethyltryptamines in a Model of Light-Induced Retinal Degeneration." Pazur, E. J.; Kalatanova, A.; Tasker, N. R.; Vainionpää, K.; Leinonen, H.; Wipf, P. ACS Med. Chem. Lett. 2024, 15(7), 1049–1056.

"Mitigation of Fetal Radiation Injury from Mid-Gestation Total-Body Irradiation by Maternal Administration of Mitochondrial-Targeted GS-Nitroxide JP4-039." Wu, Y. L.; Christodoulou, A. G.; Beumer, J. H.; Rigatti, L. H.; Fisher, R.; Ross, M.; Watkins, S.; Cortes, D. R. E.; Ruck, C.; Manzoor, S.; Wyman, S. K.; Stapleton, M. C.; Goetzman, E.; Bharathi, S.; Wipf, P.; Wang, H.; Tan, T.; Christner, S. M.; Guo, J.; Lo, C. W. Y.; Epperly, M. W.; Greenberger, J. S. Radiat. Res.2024, 202(3), 565–579.

"SARS-CoV-2 Spike Protein Induces Oxidative Stress and Senescence in Mouse and Human Lung." Greenberger, J. S.; Hou, W. E. N.; Shields, D.; Fisher, R.; Epperly, M. W.; Sarkaria, I.; Wipf, P.; Wang, H. In Vivo 2024, 38(4), 1546–1556.

"JP4-039, a Mitochondria-Targeted Nitroxide, Mitigates the Effect of Apoptosis and Inflammatory Cell Migration in the Irradiated Mouse Retina." Adeghate, J. O.; Epperly, M. W.; Davoli, K. A.; Lathrop, K. L.; Wipf, P.; Hou, W.; Fisher, R.; Thermozier, S.; Huq, M. S.; Sahel, J.-A.; Greenberger, J. S.; Eller, A. W. Int. J. Mol. Sci. 2024, 25(12), 6515.

“Ferroptosis-Induced Metabolic Shifts in Cardiac Cells: Exploring the Influence of Glutaminolysis,” Rodríguez-Graciani, K. M.; Chapa-Dubocq, X. R.; Ayala-Arroyo, E. J.;Chaves-Negrón, I.; Jang, S.; Chorna, N.; Maskrey, T. S.; Wipf, P.; Javadov, S. New Visions in Medicine and Medical Science 2024, 5, 65-90

“Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins,” Edward Chuang, Ryan R. Cupo, Jeffrey R. Bevan, Mikhaila L. Rice, Shuli Mao, Erica L. Gorenberg, Korrie L. Mack, Donna M. Huryn, Peter Wipf, Jeffrey L. Brodsky, James Shorter bioRxiv 2024, 575109

“Concise total syntheses of lysergene, lysergine, isolysergine and festuclavine,” Nikhil R. Tasker and Peter Wipf Arkivoc 2024, 2, 202312120

“Synthesis of 13C-methyl-labeled amino acids and their incorporation into proteins in mammalian cells,” Matteo Borgini, Lukasz Wieteska, Cynthia S. Hinck, Troy Krzysiak, Andrew P. Hinck*, Peter Wipf* Org. Biomol. Chem. 2023, 21, 9216-9229

“Biological studies of clavine alkaloids targeting CNS receptors,” Nikhil R. Tasker, Ethan J. Pazur, Peter Wipf* Front. Psychiatry 2023, 14, 1286941

“Hydroxamic Acids as PARP-1 Inhibitors: Molecular Design and Anticancer Activity of Novel Phenanthridinones,” Bondar, D.; Bragina, O.; Lee, J. Y.; Semenyuta, I.; Järving, I.; Brovarets, V.; Wipf, P.; Bahar, I.; Karpichev, Y. Helv. Chim. Acta (Special Issue in Honor of Professor Dr. Andrea Vasella) 2023, 1026 10, e202300133

“C3-Functionalization of indoles with α-heteroaryl-substituted methyl alcohols,” Ethan J. Pazur, Nikhil R. Tasker, Peter Wipf* Org. Biomol. Chem. 2023, 21, 8651-8657

“A cross-sectional study of ageing at the mouse neuromuscular junction and effects of an experimental therapeutic approach for dynapenia,” Li, Y.; Patel, M.; Baroudi, J.; Wu, M.; Gatti, S.; Liang, M.; Wipf, P.; Badawi, Y.; Meriney, S. D. J. Physiol. 2023, 601 18, 4135-4150

“Hydrozirconation of Alkynes,” Milligan, J. A.; Hammill, C. V.; Crocker, D. L.; Wipf, P Org. React. 2023, 113, 457-794

“Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors,” Zhu, J.; Lei, S.; Lu, J.; Hao, Y.; Qian, Q.; Devanathan, A. S.; Feng, Z.; Xie, X.-Q.; Wipf, P.; Ma, X. Eur. J. Med. Chem. 2023, 259, 115666

“Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF),” Mukherjee, A.; Epperly, M. W.; Fisher, R.; Hou, W.; Shields, D.; Saiful Huq, M.; Pifer, P. M.; Mulherkar, R.; Wilhite, T. J.; Wang, H.; Wipf, P.; Greenberger, J. S. Cell Death Discov. 2023, 9 1, 252

“Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer,” LaPorte, M. G.; Alverez, C.; Chatterley, A.; Kovaliov, M.; Carder, E. J.; Houghton, M. J.; Lim, C.; Miller, E. R.; Samankumara, L. P.; Liang, M.; Kerrigan, K.; Yue, Z.; Li, S.; Tomaino, F.; Wang, F.; Green, N.; Stott, G. M.; Srivastava, A.; Chou, T.-F.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2023, 14 7, 977-985

“Synthesis of Veliparib Prodrugs and Determination of Drug-Release-Dependent PARP-1 Inhibition,” Borgini, M.; Wipf, P. ACS Med. Chem. Lett. 2023, 14 5, 652-657

“Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model,” Ojala, K. S.; Kaufhold, C. J.; Davey, M. R.; Yang, D.; Liang, M.; Wipf, P.; Badawi, Y.; Meriney, S. D. Hum. Mol. Genet. 2023, 32 11, 1901-1911

“Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress,” Sannino, S.; Manuel, A. M.; Shang, C.; Wendell, S. G.; Wipf, P.; Brodsky, J. L. Mol. Canc. Res. 2023, 21, 675-690

“Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys,” Airik, M.; Arbore, H.; Childs, E.; Huynh, A. B.; Phua, Y. L.; Chen, C. W.; Aird, K.; Bharathi, S.; Zhang, B.; Conlon, P.; Kmoch, S.; Kidd, K.; Bleyer, A. J.; Vockley, J.; Goetzman, E.; Wipf, P.; Airik, R. Antioxidants 2023, 12 4, 900

“Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase,” Lazo, J. S.; Isbell, K. N.; Vasa, S. A.; Llaneza, D. C.; Rastelli, E. J.; Wipf, P.; Sharlow, E. R. J. Pharmacol. Exp. Ther. 2023, 384 3, 429

“Small Molecule Inhibitors of Protein Kinase D: Early Development, Current Approaches, and Future Directions,” Qiming Jane Wang*, Peter Wipf* J. Med. Chem. 2023, 66, 122-139

“Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer,” Wei, N.; Burnett, J.; Crocker, D. L.; Huang, Y.; Li, S.; Wipf, P.; Chu, E.; Schmitz, J. C. Biochem. Pharmacol. 2023, 212, 115564

"Restoring Mitochondrial Cardiolipin Homeostasis Reduces Cell Death and Promotes Recovery after Spinal Cord Injury." Liu, N.-K.; Deng, L.-X.; Wang, M.; Lu, Q.-B.; Wang, C.; Wu, X.; Wu, W.; Wang, Y.; Qu, W.; Han, Q.; Xia, Y.; Ravenscraft, B.; Li, J.-L.; You, S.-W.; Wipf, P.; Han, X.; Xu, X.-M. Cell Death Dis. 2022, 13(12), 1058

"How Mono- and Diphosphine Ligands Alter Regioselectivity of the Rh-Catalyzed Annulative Cleavage of Bicyclo[1.1.0]butanes." Chen, P.-P.; Wipf, P.; Houk, K. N. Nat. Commun. 2022, 13(1), 7292.

"A Short Synthesis of Ergot Alkaloids and Evaluation of the 5-HT1/2 Receptor Selectivity of Lysergols and Isolysergols." Tasker, N. R.; Wipf, P. Org. Lett. 2022, 24(34), 6341-6345.

"Stereoselective Synthesis of Δ-Fluorinated Isoleucines Exploiting Consecutive C(Sp3)-H Bond Activations." Borgini, M.; Wipf, P. Tetrahedron (Special Issue in Honor of Professor Dr. Franziska Schoenebeck for the 2022 Tetrahedron Young Investigator Award in Organic Synthesis) 2022, 132876.

"Development of an Automated Screen for Kv7.2 Potassium Channels and Discovery of a New Agonist Chemotype." Hernandez, C. C.; Tarfa, R. A.; Miguel I. Limcaoco, J.; Liu, R.; Mondal, P.; Hill, C.; Keith Duncan, R.; Tzounopoulos, T.; Stephenson, C. R. J.; O'Meara, M. J.; Wipf, P. Bioorg. Med. Chem. Lett. 2022, 71, 128841.

"Synthesis of Benzo[d]pyrrolo[1,2-a]imidazoles by Iminocyclopropane Rearrangement of C-Cyclopropyl Benzimidazoles." Montoya, A. P.; LaPorte, M. G.; Wipf, P. Heterocycles (Special Issue in Honor of Prof. Somsak Ruchirawat) 2022, 105(1), 358-367.

"Recent Syntheses and Biological Profiling of Quassinoids." Pazur, E. J.; Wipf, P. Org. Biomol. Chem. 2022, 20, 3870-3889.

"Synthesis and Optimization of Nitroxide-Based Inhibitors of Ferroptotic Cell Death in Cancer Cells and Macrophages." Charaschanya, M.; Maskrey, T. S.; LaPorte, M. G.; Janjic, J. M.; Wipf, P. ACS Med. Chem. Lett. 2022, 13(3), 403-408.

"Effects of Ferroptosis on the Metabolome in Cardiac Cells: The Role of Glutaminolysis." Rodríguez-Graciani, K. M.; Chapa-Dubocq, X. R.; Ayala-Arroyo, E. J.; Chaves-Negrón, I.; Jang, S.; Chorna, N.; S. Maskrey, T.; Wipf, P.; Javadov, S. Antioxidants 2022, 11(2), 278.

"A Double-Pronged Sword: XJB-5-131 is a Suppressor of Somatic Instability and Toxicity in Huntington’s Disease." Wipf, P.; Polyzos, A. A.; McMurray, C. T. J. Huntingtons Dis. 2022, 11(1), 3-15.

"(+)-JJ-74-138 Is a Novel Non-Competitive Androgen Receptor Antagonist." Cole, R. N.; Chen, W.; Pascal, L. E.; Nelson, J. B.; Wipf, P.; Wang, Z. Mol. Cancer Ther. 2022, 21(4), 483-492.

"Synthesis of sp3-Rich Chiral Bicyclo[3.3.1]nonanes for Chemical Space Expansion and Study of Biological Activities." Ueda, H.; Wipf, P.; Nakamura, H. Bioorg. Med. Chem. 2022, 54, 116561.

"Toll-Like Receptor 4–Mediated Enteric Glia Loss is Critical for the Development of Necrotizing Enterocolitis." Kovler, M. L.; Gonzalez, S. A. J.; Fulton, W. B.; Lu, P.; Yamaguchi, Y.; Zhou, Q.; Sampah, M.; Ishiyama, A.; Prindle, T.; Wang, S.; Jia, H.; Wipf, P.; Sodhi, C.; Hackam, D. Sci. Transl. Med. 2021, 13(612), eabg3459.

"Heat Shock Protein 70 as a Sex-Skewed Regulator of α-Synucleinopathy." Bhatia, T. N.; Clark, R. N.; Needham, P. G.; Miner, K. M.; Jamenis, A. S.; Eckhoff, E. A.; Abraham, N.; Hu, X.; Wipf, P.; Luk, K. C.; Brodsky, J. L.; Leak, R. K. Neurotherapeutics 2021, 18(4), 2541-2564.

"Improved Correction of F508del-CFTR Biogenesis with a Folding Facilitator and an Inhibitor of Protein Ubiquitination." Goeckeler-Fried, J. L.; Aldrin Denny, R.; Joshi, D.; Hill, C.; Larsen, M. B.; Chiang, A. N.; Frizzell, R. A.; Wipf, P.; Sorscher, E. J.; Brodsky, J. L. Bioorg. Med. Chem. Lett. 2021, 48, 128243.

"Combined Injury: Irradiation with Skin or Bone Wounds in Rodent Models." Glowacki, J.; Bellare, A.; Epperly, M. W.; Wipf, P.; Greenberger, J. S. J Radiol Prot 2021, 41(4), S561-S577.

"Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer." Lazo, J. S.; Sharlow, E. R.; Cornelison, R.; Hart, D. J.; Llaneza, D. C.; Mendelson, A. J.; Lazo, J. S.; Sharlow, E. R.; Cornelison, R.; Rastelli, E. J.; Tasker, N. R.; Wipf, P.; Landen, C. N., Jr. Biomolecules 2021, 11(7), 969.

"Unique Integrated Stress Response Sensors Regulate Cancer Cell Susceptibility When Hsp70 Activity Is Compromised." Sannino, S.; Yates, M. E.; Brodsky, J. L.; Schurdak, M. E.; Oesterreich, S.; Lee, A. V.; Wipf, P. eLife 2021, 10, e64977.

"Synthesis and Evaluation of Bifunctional PTP4A3 Phosphatase Inhibitors Activating the ER Stress Pathway." Rastelli, E. J.; Sannino, S.; Hart, D. J.; Sharlow, E. R.; Lazo, J. S.; Brodsky, J. L.; Wipf, P. Bioorg. Med. Chem. Lett. 2021, 46, 128167.

"Affinity Capture of p97 with Small-Molecule Ligand Bait Reveals a 3.6 Å Double-Hexamer Cryoelectron Microscopy Structure." Hoq, M. R.; Vago, F. S.; Li, K.; Kovaliov, M.; Nicholas, R. J.; Huryn, D. M.; Wipf, P.; Jiang, W.; Thompson, D. H. ACS Nano 2021, 15(5), 8376-8385.

"Semipinacol-Type Rearrangements of [3-(Arylsulfonyl)bicyclo[1.1.0]butan-1-yl]alkanols." Kerner, M. J.; Wipf, P. Org. Lett. 2021, 23(9), 3615-3619.

"Maternal Aryl Hydrocarbon Receptor Activation Protects Newborns against Necrotizing Enterocolitis." Lu, P.; Yamaguchi, Y.; Fulton, W. B.; Wang, S.; Zhou, Q.; Jia, H.; Kovler, M. L.; Salazar, A. G.; Sampah, M.; Prindle, T.; Wipf, P.; Sodhi, C. P.; Hackam, D. J. Nat. Commun. 2021, 12(1), 1042.

"Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity Via the HIF2α—Ve-Cadherin Pathway." Rand, D.; Ravid, O.; Atrakchi, D.; Israelov, H.; Bresler, Y.; Shemesh, C.; Omesi, L.; Liraz-Zaltsman, S.; Gosselet, F.; Maskrey, T. S.; Beeri, M. S.; Wipf, P.; Cooper, I. Pharmaceutics 2021, 13(3), 311.

"Chemical Modulation of Kv7 Potassium Channels." Borgini, M.; Mondal, P.; Liu, R.; Wipf, P. RSC Med. Chem. 2021, 12, 483-537.

"3D-Printed Cartridge System for in-Flow Photo-Oxygenation of 7-Aminothienopyridinones." Rastelli, E. J.; Yue, D.; Millard, C.; Wipf, P. Tetrahedron 2021, 79, 131875.

"Intramolecular Diels–Alder Reactions of Oxazoles, Imidazoles, and Thiazoles." Nguyen, T. T.; Wipf, P. Synthesis 2021, 53, 1181-1199.

"Regulation and Targeting of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer." Lv, S.; Song, Q.; Chen, G.; Cheng, E.; Chen, W.; Cole, R.; Wu, Z.; Pascal, L. E.; Wang, K.; Wipf, P.; Nelson, J. B.; Wei, Q.; Huang, W.; Wang, Z. J. Clin. Invest. 2021, 131(4), e141335.

"Delivery of a Mitochondria-Targeted Antioxidant from Biocompatible, Polymeric Nanofibrous Scaffolds." Hamedani, Y.; Teixeira, R. B.; Karbasiafshar, C.; Wipf, P.; Bhowmick, S.; Abid, M. R. FEBS Open Bio 2021, 11, 35-47.

"The Human Milk Oligosaccharides 2'-Fucosyllactose and 6'-Sialyllactose Protect against the Development of Necrotizing Enterocolitis by Inhibiting Toll-Like Receptor 4 Signaling." Sodhi, C. P.; Wipf, P.; Yamaguchi, Y.; Fulton, W. B.; Kovler, M.; Nino, D. F.; Zhou, Q.; Banfield, E.; Werts, A. D.; Ladd, M. R.; Buck, R. H.; Goehring, K. C.; Prindle, T., Jr.; Wang, S.; Jia, H.; Lu, P.; Hackam, D. J. Pediatr. Res. 2021, 89, 91-101.

"Biosynthesis, Total Synthesis, and Biological Profiles of Ergot Alkaloids." Tasker, N. R.; Wipf, P. The Alkaloids: Chemistry and Biology 2021, 85, 1-112. Editor: Hans-Joachim Knölker; Academic Press.

"The Mitochondrial-Targeted Reactive Species Scavenger JP4-039 Prevents Sulfite-Induced Alterations in Antioxidant Defenses, Energy Transfer, and Cell Death Signaling in Striatum of Rats." Glänzel, N. M.; Grings, M.; da Rosa-Junior, N. T.; de Carvalho, L. M. C.; Mohsen, A.-W.; Wipf, P.; Wajner, M.; Vockley, J.; Leipnitz, G. J. Inherit. Metab. Dis. 2021, 44, 481-491.

"Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis in Vitro, in Vivo, and Ex Vivo." Mlakar, L.; Lane, J.; Takihara, T.; Lim, C.; Sprachman, M. M.; Lloyd, K. R.; Wipf, P.; Feghali-Bostwick, C. ACS Med. Chem. Lett. 2020, 11(11), 2312-2317.

"Direct Involvement of Hsp70 ATP Hydrolysis in Ubr1-Dependent Quality Control." Singh, A.; Vashistha, N.; Heck, J.; Tang, X.; Wipf, P.; Brodsky, J. L. Hampton, R. Y. Mol. Biol. Cell 2020, 31(24), 2669-2686.

"Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin." Czub, M. P.; Boulton, A. M.; Rastelli, E. J.; Tasker, N. R.; Maskrey, T. S.; Blanco, I. K.; McQueeney, K. E.; Bushweller, J. H.; Minor, W.; Wipf, P.; Sharlow, E. R.; Lazo, J. S. Mol. Pharmacol. 2020, 98(6), 648-657.

"Presenting a Special Issue on Medicinal Chemistry: From Targets to Therapies." Maryanoff, B. E.; Wipf, P. ACS Med. Chem. Lett. 2020, 11(10), 1780-1782.

"Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity." Deng, F.; Ghemtio, L.; Grazhdankin, E.; Wipf, P.; Xhaard, H.; Kidron, H. Mol. Pharmaceutics 2020, 17(7), 2398-2410.

"Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington’s Disease." Terrab, L.; Rosenker, C. J.; Johnstone, L.; Ngo, L. K.; Zhang, L.; Ware, N. F.; Miller, B.; Topacio, A. Z.; Sannino, S.; Brodsky, J. L.; Wipf, P. ACS Med. Chem. Lett. 2020, 119(5), 984-990.

"Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs That Block Apoptosis and Necroptosis." Thermozier, S.; Hou, W.; Zhang, X.; Shields, D.; Fisher, R.; Bayir, H.; Kagan, V.; Yu, J.; Liu, B.; Bahar, I.; Epperly, M. W.; Wipf, P.; Wang, H.; Huq, M. S.; Greenberger, J. S. Radiat. Res. 2020, 193, 435-450.

"Arsenic Stimulates Myoblast Mitochondrial Epidermal Growth Factor Receptor to Impair Myogenesis." Cheikhi, A.; Anguiano, T.; Lasak, J.; Qian, B.; Sahu, A.; Mimiya, H.; Cohen, C. C.; Wipf, P.; Ambrosio, F.; Barchowsky, A. Toxicol. Sci. 2020, 176(1), 162-174.

"Formation of 6-Azaindoles by Intramolecular Diels-Alder Reaction of Oxazoles and Total Synthesis of Marinoquinoline A." Osano, M.; Jhaveri, D. P.; Wipf, P. Org. Lett. 2020, 22(6), 2215-2219.

"Hsp70 and the Unfolded Protein Response as a Challenging Drug Target and an Inspiration for Probe Molecule Development." Terrab, L.; Wipf, P. ACS Med. Chem. Lett. 2020, 11(3), 232-236.

"A Novel Androgen Receptor Antagonist JJ-450 Inhibits Enzalutamide-Resistant Mutant ARF876L Nuclear Import and Function." Wu, Z.; Wang, K.; Yang, Z.; Pascal, L. E.; Nelson, J. B.; Takubo, K.; Wipf, P.; Wang, Z. Prostate 2020, 80, 319-328.

"A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer." Yang, Z.; Wang, D.; Johnson, J. K.; Pascal, L. E.; Takubo, K.; Avula, R.; Chakka, A. B.; Zhou, J.; Chen, W.; Zhong, M.; Song, Q.; Ding, H.; Wu, Z.; Chandran, U. R.; Maskrey, T. S.; Nelson, J. B.; Wipf, P.; Wang, Z. Mol. Cancer Ther. 2020, 19(1), 75-88.

"Second-Generation Probiotics Producing IL-22 Increase Survival of Mice after Total Body Irradiation." Zhang, X.; Fisher, R.; Hou, W.; Shields, D.; Epperly, M. W.; Wang, H.; Wei, L.; Leibowitz, B. J.; Yu, J.; Alexander, L. M.; van Pijkeren, J.-P.; Watkins, S.; Wipf, P.; Greenberger, J. S. In Vivo 2020, 34(1), 39-50.

"Fanconi Anemia Mouse Genotype-Specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039." Epperly, M. W.; Fisher, R.; Zhang, X.; Hou, W.; Shields, D.; Wipf, P.; Wang, H.; Thermozier, S.; Greenberger, J. S. In Vivo 2020, 34(1), 33-38.

"p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections."Huryn, D. M.; Kornfilt, D. J. P.; Wipf, P. J. Med. Chem. 2020, 63(5), 1892-1907.

"PTPRT Epigenetic Silencing Defines Lung Cancer with STAT3 Activation and Can Direct STAT3 Targeted Therapies." Sen, M.; Kindsfather, A.; Danilova, L.; Zhang, F.; Colombo, R.; LaPorte, M. G.; Kurland, B. F.; Huryn, D. M.; Wipf, P.; Herman, J. G. Epigenetics 2020, 15(6-7), 604-617.

"Synthesis of 4-Nitrophenyl (2,2,6,6-Tetramethylpiperidin-1-yl) Carbonate (NPTC) for N-Protection of l-Phenylalanine Ethyl Ester." Lizza, J.; Wipf, P. Org. Synth. 2020, 97, 96-124.