As an emerging approach to protein perturbation, small molecule-induced protein degradation has gained significant attention as both a chemical tool and a potential therapeutic. To enable discrete control over its function, we have developed a broadly applicable approach for the optical activation of small molecule-induced protein degradation. By installing two different photolabile protecting groups, so-called caging groups, onto two different ligands recruiting Von Hippel–Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered protein degradation for any small molecule warhead.
Title of journal, book, etc.
J. Am. Chem. Soc.Naro, Y., Darrah, K., Deiters, A.,
URL
https://doi.org/10.1021/jacs.9b12718Page Information
2193−2197Volume
142