Department of Chemistry

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Scott Nelson

Professor

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503 CHVRN
Chevron Science Center, 219 Parkman Avenue

Pittsburgh, PA 15260
412-624-4290

Research Overview

Developing new reaction technology for the rapid and efficient construction of therapeutically relevant compounds forms the cornerstone of our research program. Reaction development efforts focus primarily on devising metal-based catalytic protocols for executing stereoselective bond constructions. Our principle objective is the rapid and economical preparation of optically active small-molecule building blocks that relate directly to the complex stereochemical and structural motifs embedded in natural product target molecules.

Awards

  • Bristol-Myers Squibb Foundation, Award for Synthetic Chemistry (2001)
  • Eli Lilly & Co., Award for Synthetic Organic Chemistry (2002)
  • Chancellorís Distinguished Research Award (2002)

Publications

“Catalytic Asymmetric Aldol Equivalents in the Enantioselective Synthesis of the Apoptolidin C Aglycone,” Vargo TR, Hale JS, Nelson SG Angewandte Chemie-International Edition 2010, 49, 8678-8681
“Catalytic Asymmetric Claisen Rearrangement of Unactivated Allyl Vinyl Ethers,” Geherty ME, Dura RD, Nelson SG Journal of the American Chemical Society 2010, 132, 11875-11877
“Catalytic Asymmetric Synthesis of Complex Polypropionates: Lewis Base Catalyzed Aldol Equivalents in the Synthesis of Erythronolide B,” Chandra B, Fu DZ, Nelson SG ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2010, 49, 2591-2594
“High-Content Analysis of Cancer-Cell-Specific Apoptosis and Inhibition of in Vivo Angiogenesis by Synthetic (-)-Pironetin and Analogs,” Vogt A, McPherson PA, Shen XQ, Balachandran R, Zhu GY, Raccor BS, Nelson SG, Tsang M, Day BW CHEMICAL BIOLOGY & DRUG DESIGN 2009, 74, 358-368
“Automated Image-Based Phenotypic Analysis in Zebrafish Embryos,” Vogt A, Cholewinski A, Shen XQ, Nelson SG, Lazo, JS, Tsang M, Hukriede NA DEVELOPMENTAL DYNAMICS 2009, 238, 656-663
“Pd(II)-catalyzed aliphatic Claisen rearrangements of acyclic allyl vinyl ethers,” Kerrigan NJ, Bungard CJ, Nelson SG TETRAHEDRON 2008, 64, 6863-6869
“[4+2] cycloadditions of N-alkenyl iminium ions: Structurally complex heterocycles from a three-component Diels-Alder reaction sequence,” Sarkar N, Banerjee A, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2008, 130, 9222
“The azido acid approach to beta-peptides: parallel synthesis of a tri-beta-peptide library by fluorous tagging,” Wang X, Nelson SG, Curran DP TETRAHEDRON 2007, 63, 6141-6145
“Stereoselective olefin isomerization leading to asymmetric quaternary carbon construction,” Wang K, Bungard CJ, Nelson SG ORGANIC LETTERS 2007, 9, 2325-2328
“Au(I)-catalyzed annulation of enantioenriched allenes in the enantioselective total synthesis of (-)-rhazinilam,” Liu ZS, Wasmuth AS, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2006, 128, 10352-10353
“Strategies for expanding structural diversity available from olefin isomerization - Claisen rearrangement reactions,” Stevens BD, Bungard CJ, Nelson SG JOURNAL OF ORGANIC CHEMISTRY 2006, 71, 6397-6402
“Catalytic asymmetric assembly of stereodefined propionate units: An enantioselective total synthesis of (-)-pironetin,” Shen XQ, Wasmuth AS, Zhao JP, Zhu C, Nelson SG JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2006, 128, 7438-7439