Department of Chemistry

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Peter Wipf

Distinguished University Professor

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758 CHVRN
Chevron Science Center, 219 Parkman Avenue

Pittsburgh, PA 15260
412-624-8606

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Research Overview

Total Synthesis of Natural Products; Organometallic and Heterocyclic Chemistry; Medicinal Chemistry

Total Synthesis of Natural Products

Total Synthesis encompasses all aspects of organic chemistry: The development of new methodology, mechanistic and physical organic experiments, conformational and configurational analysis by spectroscopic and computational methods, and bioorganic and medicinal chemistry. Total Synthesis is also one of the broadest and most rewarding educational experiences for aspiring synthetic chemists.

Organometallic Chemistry

Organometallic Chemistry will provide most of new revolutionary techniques for C,C and C-heteroatom bond formations and asymmetric catalysis. Our group has had a long tradition in synthetic applications of transition metals.

Heterocyclic Chemistry

More than half of all known organic compounds, and the vast majority of drugs, are heterocyclic. We are interested in the development of new stereoselective methods for the preparation of highly functionalized heterocycles. In particular, we have developed novel protocols for five-membered heterocycle synthesis that have been widely adopted in industry and academe.

Combinatorial Synthesis & Medicinal Chemistry

We apply combinatorial chemistry and solid phase synthesis methods for reagent and catalyst design in organometallic and heterocyclic chemistry, and for the structure-activity analysis of bioactive natural products. Specifically, we are involved in collaborative drug discovery and development. Some of these projects take advantage of the infrastructure of the Combinatorial Chemistry Center (CCC).

 

Computational Prediction of Macroscopic Properties

In another exciting interdisciplinary collaboration, we have joined forces with the Beratan group for the computational assignment of the relative and absolute stereochemistry of organic molecules of organic molecules and the theoretical prediction of chiroptical phenomena.

 

 

 

The Wipf Group is currently accepting new graduate students.

Recent Advisory And Editorial Boards

  • Editorial Advisory Board, Helvetica Chimica Acta (2016-present)

  • ACS National Awards Selection Committee (2015)

  • Guest Editor for Israel Journal of Chemistry Special Issue on “Flow Chemistry”

  • Organic Syntheses, Inc., Board of Directors (2013-present)

  • Guest Editor for Molecules Special Issue on “Diversity Oriented Synthesis” (2011)

  • External Advisory Committee, Purdue University Center for Cancer Research, West Lafayette, IN (2010-present)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009)-present

  • Honorary Editorial Board, International Journal of High Throughput Screening (2009-present)

  • Organic Reactions, Inc., Board of Directors (2007-present)

  • International Advisory Editorial Board, Organic & Biomolecular Chemistry (2007-present)

Awards

  • ACS Award for Creative Work in Synthetic Organic Chemistry (2023)
  • Vice President, Organic Syntheses, Inc. (2021-present)
  • Stanford University Ranking in Top 0.04% of Scientists in the World (2020)
  • Visiting Professor, RWTH Aachen, Aachen, Germany (2016)
  • Chair of the Section on Pharmaceutical Sciences of the American Association for the Advancement of Science (2016)
  • Provost's Award for Excellence in Mentoring (2015)
  • Humboldt Research Award of the Alexander von Humboldt Foundation (2014)
  • Harry and Carol Mosher Award of the Santa Clara Valley Section of the ACS (2013)
  • Edward W. Morley Award of the Cleveland Section of the ACS (2013)

  • ACS Pittsburgh Award (2012)

  • Fellow of the American Chemical Society (2010)

  • Ernest Guenther Award in the Chemistry of Natural Products (2009)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009-present)

  • Organic Reactions, Inc. Board of Directors (2007-present)

  • Chancellor's Distinguished Research Award (2008)

  • Faculty of 1000 Biology (2006-present)

  • Novartis Chemistry Lectureship (2005)

  • Fellow of the Royal Society of Chemistry (FRSC, 2004)

  • Visiting Professor (Professeur Associé), École Supérieur de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), Paris, France (September 2004)
  • Long Range Planning Committee, ACS Division of Medicinal Chemistry (2004-2006)
  • ISHC Katritzky Award in Heterocyclic Chemistry (2003)

  • Fellow of the American Association for the Advancement of Science (AAAS, 2002)
  • Chair, Gordon Research Conference on Stereochemistry, Salve Regina University, Newport, Rhode Island (June 9-14, 2002)
  • Visiting Professor (Professeur Associé), Université de Paris-Sud, Orsay, France (November 2001)
  • Member-at-Large, Organic Division Executive Committee of the ACS (2001-2003)
  • Novartis Research Award (2000, 2001)
  • Japan Society for the Promotion of Science Fellow (2000)

  • Akron Section ACS Award (1998)

  • Arthur C. Cope Scholar Award (1998)

  • NIH Medicinal Chemistry Study Section, Member, 1998-2003, Chairman, 2001-2003

  • Chancellorís Distinguished Research Award (1997)

  • Phi Eta Sigma, Honorary Member (1996)

  • Merck Young Investigator Award (1995)

  • Zeneca Award for Excellence in Chemistry (1995)

  • Camille Dreyfus Teacher-Scholar Award (1995)

  • UCI-Allergan Visiting Lecturer, University of California, Irvine, California (May, 1995)
  • NSF Presidential Faculty Fellow (1994-1999)

  • ETH Ruzicka Award (1994)

  • Alfred P. Sloan Research Fellow (1994-1996)

  • American Cyanamid Faculty Award (1994)

  • Eli Lilly Grantee (1993-1995)

  • University of Zürich, Distinguished Dissertation Award (1987)


Publications

“Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins,” Edward Chuang, Ryan R. Cupo, Jeffrey R. Bevan, Mikhaila L. Rice, Shuli Mao, Erica L. Gorenberg, Korrie L. Mack, Donna M. Huryn, Peter Wipf, Jeffrey L. Brodsky, James Shorter bioRxiv 2024, 575109
“Concise total syntheses of lysergene, lysergine, isolysergine and festuclavine,” Nikhil R. Tasker and Peter Wipf Arkivoc 2024, 2, 202312120
“Synthesis of 13C-methyl-labeled amino acids and their incorporation into proteins in mammalian cells,” Matteo Borgini, Lukasz Wieteska, Cynthia S. Hinck, Troy Krzysiak, Andrew P. Hinck*, Peter Wipf* Org. Biomol. Chem. 2023, 21, 9216-9229
“Biological studies of clavine alkaloids targeting CNS receptors,” Nikhil R. Tasker, Ethan J. Pazur, Peter Wipf* Front. Psychiatry 2023, 14, 1286941
“Hydroxamic Acids as PARP-1 Inhibitors: Molecular Design and Anticancer Activity of Novel Phenanthridinones,” Bondar, D.; Bragina, O.; Lee, J. Y.; Semenyuta, I.; Järving, I.; Brovarets, V.; Wipf, P.; Bahar, I.; Karpichev, Y. Helv. Chim. Acta (Special Issue in Honor of Professor Dr. Andrea Vasella) 2023, 1026 10, e202300133
“C3-Functionalization of indoles with α-heteroaryl-substituted methyl alcohols,” Ethan J. Pazur, Nikhil R. Tasker, Peter Wipf* Org. Biomol. Chem. 2023, 21, 8651-8657
“A cross-sectional study of ageing at the mouse neuromuscular junction and effects of an experimental therapeutic approach for dynapenia,” Li, Y.; Patel, M.; Baroudi, J.; Wu, M.; Gatti, S.; Liang, M.; Wipf, P.; Badawi, Y.; Meriney, S. D. J. Physiol. 2023, 601 18, 4135-4150
“Hydrozirconation of Alkynes,” Milligan, J. A.; Hammill, C. V.; Crocker, D. L.; Wipf, P Org. React. 2023, 113, 457-794
“Metabolism-guided development of Ko143 analogs as ABCG2 inhibitors,” Zhu, J.; Lei, S.; Lu, J.; Hao, Y.; Qian, Q.; Devanathan, A. S.; Feng, Z.; Xie, X.-Q.; Wipf, P.; Ma, X.  Eur. J. Med. Chem. 2023, 259, 115666
“Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF),” Mukherjee, A.; Epperly, M. W.; Fisher, R.; Hou, W.; Shields, D.; Saiful Huq, M.; Pifer, P. M.; Mulherkar, R.; Wilhite, T. J.; Wang, H.; Wipf, P.; Greenberger, J. S. Cell Death Discov. 2023, 9 1, 252
“Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer,” LaPorte, M. G.; Alverez, C.; Chatterley, A.; Kovaliov, M.; Carder, E. J.; Houghton, M. J.; Lim, C.; Miller, E. R.; Samankumara, L. P.; Liang, M.; Kerrigan, K.; Yue, Z.; Li, S.; Tomaino, F.; Wang, F.; Green, N.; Stott, G. M.; Srivastava, A.; Chou, T.-F.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2023, 14 7, 977-985
“OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced cellular senescence,” De Rosa, M.; Barnes, R. P.; Nyalapatla, P. R.; Wipf, P.; Opresko, P. L. bioRxiv 2023
“Potentiation of neuromuscular transmission by a small molecule calcium channel gating modifier improves motor function in a severe spinal muscular atrophy mouse model,” Ojala, K. S.; Kaufhold, C. J.; Davey, M. R.; Yang, D.; Liang, M.; Wipf, P.; Badawi, Y.; Meriney, S. D. Hum. Mol. Genet. 2023, 32 11, 1901-1911
“Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress,” Sannino, S.; Manuel, A. M.; Shang, C.; Wendell, S. G.; Wipf, P.; Brodsky, J. L. Mol. Canc. Res. 2023, 21, 675-690
“Mitochondrial ROS Triggers KIN Pathogenesis in FAN1-Deficient Kidneys,” Airik, M.; Arbore, H.; Childs, E.; Huynh, A. B.; Phua, Y. L.; Chen, C. W.; Aird, K.; Bharathi, S.; Zhang, B.; Conlon, P.; Kmoch, S.; Kidd, K.; Bleyer, A. J.; Vockley, J.; Goetzman, E.; Wipf, P.; Airik, R. Antioxidants 2023, 12 4, 900
“Disruption of Ovarian Cancer STAT3 and p38 Signaling with a Small-Molecule Inhibitor of PTP4A3 Phosphatase,”  Lazo, J. S.; Isbell, K. N.; Vasa, S. A.; Llaneza, D. C.; Rastelli, E. J.; Wipf, P.; Sharlow, E. R. J. Pharmacol. Exp. Ther. 2023, 384 3, 429
“Quassinoid analogs exert potent antitumor activity via reversible protein biosynthesis inhibition in human colorectal cancer,” Wei, N.; Burnett, J.; Crocker, D. L.; Huang, Y.; Li, S.; Wipf, P.; Chu, E.; Schmitz, J. C.  Biochem. Pharmacol. 2023, 212, 115564
“Development of an automated screen for Kv7.2 potassium channels and discovery of a new agonist chemotype,” Ciria C. Hernandez, Rahilla A. Tarfa, Jose Miguel I. Limcaoco, Ruiting Liu, Pravat Mondal, Clare Hill, Keith R. Duncan, Thanos Tzounopoulos, Corey R.J. Stephenson, Matthew J. O'Meara, Peter Wipf Bioorg. Med. Chem. Lett. 2022, 71, 128841
“Recent syntheses and biological profiling of quassinoids,” Ethan J. Pazur, Peter Wipf Org. Biomol. Chem. 2022, 20, 3870-3889
“Chemical modulation of Kv7 potassium channels,” Matteo Borgini, Pravat Mondal, Ruiting Liu, Peter Wipf RSC Med. Chem. 2021, 12, 483 - 537
“3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones,” Ettore Rastelli, Doris Yue, Caroline Millard, Peter Wipf Tetrahedron 2021, 79, 131875
“Chapter One - Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids,” Nikhil R. Tasker, Peter Wipf The Alkaloids 2021, 85, 1 - 112
“Presenting a Special Issue on "Medicinal Chemistry: From Targets to Therapies ,” Maryanoff, B. E.; Wipf, P. ACS Med. Chem. Lett. 2020, 11 10, 1780-1782
“One-Pot Two-Step Synthesis of Isochromene-Fused CF3-Substituted Pyrazoles,” Nikolic, A. M.; Zivkovic, F.; Selakovic, Z.; Wipf, P.; Opsenica, I. M.  Eur. J. Org. Chem. 2020, 34, 5616-5619
“Binding Site Interactions of Modulators of Breast Cancer Resistance Protein, Multidrug Resistance-Associated Protein 2, and P-Glycoprotein Activity,” Deng, F.; Ghemtio, L.; Grazhdankin, E.; Wipf, P.; Xhaard, H.; Kidron, H.  Mol. Pharm 2020, 17 7, 2398-2410
“Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington’s Disease,” Terrab, L.; Rosenker, C. J.; Johnstone, L.; Ngo, L. K.; Zhang, L.; Ware, N. F.; Miller, B.; Topacio, A. Z.; Sannino, S.; Brodsky, J. L.; Wipf, P.  ACS Med. Chem. Lett. 2020, 119 5, 984-990
“Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs That Block Apoptosis and Necroptosis,” Thermozier, S.; Hou, W.; Zhang, X.; Shields, D.; Fisher, R.; Bayir, H.; Kagan, V.; Yu, J.; Liu, B.; Bahar, I.; Epperly, M. W.; Wipf, P.; Wang, H.; Huq, M. S.; Greenberger, J. S.  Radiat. Res. 2020, 193 5, 435-450
“A Novel Androgen Receptor Antagonist JJ-450 Inhibits Enzalutamide-Resistant Mutant ARF876L Nuclear Import and Function,” Wu, Z.; Wang, K.; Yang, Z.; Pascal, L. E.; Nelson, J. B.; Takubo, K.; Wipf, P.; Wang, Z.  Prostate 2020, 80 4, 319-328
“A Novel Small Molecule Targets Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer,” Yang, Z.; Wang, D.; Johnson, J. K.; Pascal, L. E.; Takubo, K.; Avula, R.; Chakka, A. B.; Zhou, J.; Chen, W.; Zhong, M.; Song, Q.; Ding, H.; Wu, Z.; Chandran, U. R.; Maskrey, T. S.; Nelson, J. B.; Wipf, P.; Wang, Z.  Mol. Cancer Ther. 2020, 19 1, 75-88
“Second-Generation Probiotics Producing IL-22 Increase Survival of Mice after Total Body Irradiation,” Zhang, X.; Fisher, R.; Hou, W.; Shields, D.; Epperly, M. W.; Wang, H.; Wei, L.; Leibowitz, B. J.; Yu, J.; Alexander, L. M.; van Pijkeren, J.-P.; Watkins, S.; Wipf, P.; Greenberger, J. S.  In Vivo 2020, 34 1, 39-50
“Fanconi Anemia Mouse Genotype-Specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039,” M. W.; Fisher, R.; Zhang, X.; Hou, W.; Shields, D.; Wipf, P.; Wang, H.; Thermozier, S.; Greenberger, J. S.  In Vivo 2020, 34 1, 33-38
“p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections,” Huryn, D. M.; Kornfilt, D. J. P.; Wipf, P.  J. Med. Chem. 2020, 63 5, 1892-1907
“PTPRT Epigenetic Silencing Defines Lung Cancer with STAT3 Activation and Can Direct STAT3 Targeted Therapies,” Sen, M.; Kindsfather, A.; Danilova, L.; Zhang, F.; Colombo, R.; LaPorte, M. G.; Kurland, B. F.; Huryn, D. M.; Wipf, P.; Herman, J. G.  Epigenetics 2020, 15 6-7, 604-617
“Perfluorooctane Sulfonate (PFOS) Produces Dopaminergic Neuropathology in Caenorhabditis Elegans,” Sammi, S. R.; Foguth, R. M.; Nieves, C. S.; De Perre, C.; Wipf, P.; McMurray, C. T.; Lee, L. S.; Cannon, J. R.  Toxicol. Sci. 2019, 172 2, 417-434
“Co(II)-Salen Catalyzed Stereoselective Cyclopropanation of Fluorinated Styrenes,” Tai, S.; Maskrey, T. S.; Nyalapatla, P. R.; Wipf, P.  Chirality 2019, 31 12, 1014-1027
“Next-Generation Cell-Active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase,” ." Lazo, J. S.; Blanco, I. K.; Tasker, N. R.; Rastelli, E. J.; Burnett, J. C.; Garrott, S. R.; Hart, D. J.; McCloud, R. L.; Hsu, K.-L.; Wipf, P.; Sharlow, E. R.  J. Pharmacol. Exp. Ther. 2019, 371 3, 652-662
“Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca(-/-) Mice by JP4-039,” Quinn, T. J.; Ding, X.; Li, X.; Wilson, G. D.; Buelow, K.; Sivananthan, A.; Thermozier, S.; Henderson, A.; Epperly, M. W.; Franicola, D.; Wipf, P.; Greenberger, J. S.; Stevens, C. W.; Kabolizadeh, P. In vivo 2019, 33 6, 1757-1766
“Specific RITA Modification Produces Hyperselective Cytotoxicity While Maintaining in Vivo Antitumor Efficacy,” Peyser, B. D.; Hermone, A.; Salamoun, J. M.; Burnett, J. C.; Hollingshead, M. G.; McGrath, C. F.; Gussio, R.; Wipf, P.  Mol. Cancer Ther. 2019, 18 10, 1765-1774
“ETHE1 and MOCS1 Deficiencies: Disruption of Mitochondrial Bioenergetics, Dynamics, Redox Homeostasis and Endoplasmic Reticulum-Mitochondria Crosstalk in Patient Fibroblasts,” Grings, M.; Seminotti, B.; Karunanidhi, A.; Ghaloul-Gonzalez, L.; Mohsen, A.-W.; Wipf, P.; Palmfeldt, J.; Vockley, J.; Leipnitz, G. Sci. Rep. 2019, 9 1, 12651
“Tapping the Therapeutic Potential of Protein Tyrosine Phosphatase 4A with Small Molecule Inhibitors,” Tasker, N. R.; Rastelli, E. J.; Burnett, J. C.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.  Bioorg. Med. Chem. Lett. 2019, 29 16, 2008-2015
“Medicinal Chemistry: From Targets to Therapies,” Maryanoff, B. E.; Wipf, P.  ACS Med. Chem. Lett. 2019, 10 7, 1014
“Amelioration of Amyotrophic Lateral Sclerosis in Sod1(G93a) Mice by M2 Microglia from Transplanted Marrow,” Epperly, M. W.; Fisher, R.; Zhang, X.; Hou, W.; Shields, D.; Franicola, D.; Wang, H.; Thermozier, S.; Henderson, A.; Greenberger, J. S.; Rigatti, L.; Watkins, S.; Bayir, H.; Donnelly, C.; Wipf, P.  In Vivo 2019, 33 3, 675-688
“Mitochondrial Energetics Is Impaired in Very Long-Chain Acyl-Coa Dehydrogenase Deficiency and Can Be Rescued by Treatment with Mitochondria-Targeted Electron Scavengers,” Seminotti, B.; Leipnitz, G.; Karunanidhi, A.; Kochersperger, C.; Roginskaya, V. Y.; Basu, S.; Wang, Y.; Wipf, P.; Van Houten, B.; Mohsen, A.-W.; Vockley, J.  Hum. Mol. Genet. 2019, 28 6, 928-941
“Ferroptosis as a Novel Therapeutic Target for Friedreich's Ataxia,” Cotticelli, M. G.; Xia, S.; Lin, D.; Lee, T.; Terrab, L.; Wipf, P.; Huryn, D. M.; Wilson, R. B. J. Pharmacol. Exp. Ther. 2019, 369 1, 47-54
“In-Flow Photooxygenation of Aminothienopyridinones Generates Iminopyridinedione PTP4A3 Phosphatase Inhibitors,” Tasker, N. R.; Rastelli, E. J.; Blanco, I. K.; Burnett, J. C.; Sharlow, E. R.; Lazo, J. S.; Wipf, P.  Org. Biomol. Chem. 2019, 17 9, 2448-2446
“Asymmetric Total Synthesis and Biological Evaluation of (+)-Cycloclavine,” McCabe, S. R.; Wipf, P. Synthesis 2019, 51 1, 213-224
“A New Synthesis of Gefitinib,” Maskrey, T. S.; Kristufek, T.; LaPorte, M. G.; Nyalapatla, P. R.; Wipf, P.  Synlett 2019, 30 4, 471-476
“Synthesis and Evaluation of Esterified Hsp70 Agonists in Cellular Models of Protein Aggregation and Folding,” Chiang, A. N.; Liang, M.; Dominguez-Meijide, A.; Masaracchia, C.; Goeckeler-Fried, J. L.; Mazzone, C. S.; Newhouse, D. W.; Kendsersky, N. M.; Yates, M. E.; Manos-Turvey, A.; Needham, P. G.; Outeiro, T. F.; Wipf, P.; Brodsky, J. L. Bioorg. Med. Chem. 2019, 27 1, 79-91
“Mitochondria Are a Substrate of Cellular Memory,” Cheikhi, A.; Wallace, C.; St Croix, C.; Cohen, C.; Tang, W.-Y.; Wipf, P.; Benos, P. V.; Ambrosio, F.; Barchowsky, A.  Free Radical Biol. Med. 2019, 130, 528-541
“Hsp70 Binds to the Androgen Receptor N-Terminal Domain and Modulates the Receptor Function in Prostate Cancer Cells,” Dong, J.; Wu, Z.; Wang, D.; Pascal, L. E.; Nelson, J. B.; Wipf, P. Mol. Cancer Ther. 2019, 18 1, 39-50
“Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca(-/-)) Mice,” Sivananthan, A.; Shields, D.; Fisher, R.; Hou, W.; Zhang, X.; Franicola, D.; Epperly, M. W.; Greenberger, J. S.; Wipf, P.  Radiat. Res. 2019, 191 2, 139-153
“2,2,6,6-Tetramethylpiperidin-1-yloxycarbonyl: A Protecting Group for Primary, Secondary, and Heterocyclic Amines,” ." Lizza, J. R.; Bremerich, M.; McCabe, S. R.; Wipf, P.  Org. Lett. 2018, 20 21, 6760-6764
“Structural Basis of Polyketide Synthase O-Methylation,” Skiba, M. A.; Bivins, M. M.; Schultz, J. R.; Bernard, S. M.; Fiers, W. D.; Dan, Q.; Kulkarni, S.; Wipf, P.; Gerwick, W. H.; Sherman, D. H.; Aldrich, C. C.; Smith, J. L.  ACS Chem. Biol. 2018, 13 12, 3221-3228
“Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-Ribose) Polymerase-1 Inhibitor,” Krainz, T.; Lamade, A. M.; Du, L.; Maskrey, T. S.; Calderon, M. J.; Watkins, S. C.; Epperly, M. W.; Greenberger, J. S.; Bayir, H.; Wipf, P.; Clark, R. S. B.  ACS Chem. Biol. 2018, 13 10, 2868-2879
“Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97,” LaPorte, M. G.; Burnett, J. C.; Colombo, R.; Bulfer, S. L.; Alverez, C.; Chou, T.-F.; Neitz, R. J.; Green, N.; Moore, W. J.; Yue, Z.; Li, S.; Arkin, M. R.; Wipf, P.; Huryn, D. M. ACS Med. Chem. Lett. 2018, 9 11, 1075-1081
“Targeting P75 Neurotrophin Receptors Ameliorates Spinal Cord Injury-Induced Detrusor Sphincter Dyssynergia in Mice,” Zabbarova, I. V.; Ikeda, Y.; Carder, E. J.; Wipf, P.; Wolf-Johnston, A. S.; Birder, L. A.; Yoshimura, N.; Getchell, S. E.; Almansoori, K.; Tyagi, P.; Fry, C. H.; Drake, M. J.; Kanai, A. J.  Neurourol. Urodyn. 2018, 37 8, 2452-2461
“Relaxin-2 Therapy Reverses Radiation-Induced Fibrosis and Restores Bladder Function in Mice,” Ikeda, Y.; Zabbarova, I. V.; Birder, L. A.; Wipf, P.; Getchell, S. E.; Tyagi, P.; Fry, C. H.; Drake, M. J.; Kanai, A. J.  Neurourol. Urodyn. 2018, 37 8, 2441-2451
“A Five-Component Biginelli-Diels-Alder Cascade Reaction,” Maskrey, T. S.; Frischling, M. C.; Rice, M. R., Wipf, P. Front. Chem. 2018, 6, 376
“Compensatory Increases of Select Proteostasis Networks after Hsp70 Inhibition in Cancer Cells,” Sannino, S.; Guerriero, C. J.; Sabnis, A. J.; Stolz, D. B.; Wallace, C. T.; Wipf, P.; Watkins, S. C.; Bivona Trever, G.; Brodsky, J. L. J. Cell Sci. 2018, 131 (17)
“Genetic Re-Engineering of Polyunsaturated Phospholipid Profile of Saccharomyces Cerevisiae Identifies a Novel Role for Cld1 in Mitigating the Effects of Cardiolipin Peroxidation,”  Lou, W.; Ting, H.-C.; Reynolds, C. A.; Tyurina, Y. Y.; Tyurin, V. A.; Li, Y.; Ji, J.; Yu, W.; Liang, Z.; Stoyanovsky, D. A.; Anthonymuthu, T. S.; Frasso, M. A.; Wipf, P.; Greenberger, J. S.; Bayir, H.; Kagan, V. E.; Greenberg, M. L. Biochim. Biophys. Acta Mol. Cell Biol. L. 2018, 1863 (10), 1354-1368
“Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways,”  Steinman, J.; Epperly, M.; Hou, W.; Willis, J.; Wang, H.; Fisher, R.; Liu, B.; Bahar, I.; McCaw, T.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S.; Huq, M. S.; Greenberger, J. S.; Liu, B.; Bavar, I.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S. Rad. Res. 2018, 189, 68-83
“Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039),” Epperly, M. W.; Fisher, R.; Franicola, D.; Greenberger, J. S.; Wipf, P.; Beumer, J.; Li, S.; Brand, R. M.; Falo, L. D.; Erdos, G. In Vivo 2018, 32, (5), 1009-1023
“Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage,” Brand, R. M.; Wipf, P.; Durham, A.; Epperly, M. W.; Greenberger, J. S.; Falo, L. D., Jr. Front. Pharmcol. 2018, 9, 920
“Reevaluation of the Palladium/Carbon-Catalyzed Decarbonylation of Aliphatic Aldehydes,” Ajdacic, V.; Nikolic, A.; Kerner, M.; Wipf, P.; Opsenica, I. M. Synlett 2018, 29, 1781-1785
“A High-Content Screen Reveals New Small-Molecule Enhancers of as/Mapk Signaling as Probes for Zebrafish Heart Development,”  Saydmohammed, M.; Onuoha, E. O.; Tsang, M.; Vollmer, L. L.; Vogt, A.; Maskrey, T. S.; Wipf, P.; Gibson, G.; Watkins, S. C.; Vogt, A. Molecules 2018, 23, (7), 1691
“A Chemical Genetics Approach Identifies PTP4A3 as a Regulator of Colon Cancer Cell Adhesion,”  McQueeney, K. E.; Ahn, J. G.; Pekic, P.; Blanco, I. K.; Struckman, H. L.; Sharlow, E. R.; Lazo, J. S.; Salamoun, J. M.; Wipf, P. FASEP J. 2018
“Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fanca(-/-) and Fancg(-/-) Mice by Intraoral Administration of GS-Nitroxide (JP4-039),” Willis, J.; Epperly, M. W.; Fisher, R.; Zhang, X.; Shields, D.; Hou, W.; Wang, H.; Steinman, J.; Greenberger, J. S.; Li, S.; Wipf, P.; Parmar, K.; Guinan, E. Radiat. Res. 2018, 189, (6), 560-578
“ATF4 Regulates Cd4+ T Cell Immune Responses through Metabolic Reprogramming,” Yang, X.; Xia, R.; Yue, C.; Zhai, W.; Du, W.; Yang, Q.; Cao, H.; Chen, X.; Obando, D.; Zhu, Y.; Chen, X.; Chen, J.-J.; Piganelli, J.; Wipf, P.; Jiang, Y.; Xiao, G.; Wu, C.; Jiang, J.; Lu, B. Cell Rep. 2018, 23, (6), 1754-1766
“Targeting Ovarian Cancer and Endothelium with an Allosteric PTP4A3 Phosphatase Inhibitor,” McQueeney, K. E.; Salamoun, J. M.; Burnett, J. C.; Barabutis, N.; Lewandowski, S. L.; Llaneza, D. C.; Cornelison, R.; Bai, Y.; Zhang, Z.-Y.; Catravas, J. D.; Landen, C. N.; Wipf, P.; Lazo, J. S.; Sharlow, E. R. Oncotarget 2018, 9, (9), 8223-8240
“XJB-5-131-Mediated Improvement in Physiology and Behaviour of the R6/2 Mouse Model of Huntington's Disease Is Age- and Sex-Dependent,” Polyzos, A. A.; Williams, P.; McMurray, C. T.; Wood, N. I.; Morton, A. J.; Wipf, P. PLoS One 2018, 13, (4)
“Development of an Undergraduate Course in Chemical Laboratory Safety through an Academic/Industrial Collaboration,” Huston, E. M.; Milligan, J. A.; Powell, J. R.; Smith, A. M.; Neal, D.; Duval, K. M.; Di Nardo, M. A.; Stoddard, C.; Bell, P. A.; Berning, A. W.; Wipf, P.; Bandik, G. C. J. Chem. Educ. 2018, 95 (4), (4), 577-583
“Spontaneous DNA Damage to the Nuclear Genome Promotes Senescence, Redox Imbalance and Aging,” Robinson, A. R.; Yousefzadeh, M. J.; Rozgaja, T. A.; Wang, J.; Li, X.; Tilstra, J. S.; Feldman, C. H.; Gregg, S. Q.; Johnson, C. H.; Skoda, E. M.; Frantz, M.-C.; Bell-Temin, H.; Pope-Varsalona, H.; Gurkar, A. U.; Nasto, L. A.; Robinson, R. A. S.; Fuhrmann-Stroissnigg, H.; Czerwinska, J.; McGowan, S. J.; Cantu-Medellin, N.; Harris, J. B.; Maniar, S.; Ross, M. A.; Trussoni, C. E.; LaRusso, N. F.; Cifuentes-Pagano, E.; Pagano, P. J.; Tudek, B.; Vo, N. V.; Rigatti, L. H.; Opresko, P. L.; Beer-Stolz, D.; Watkins, S. C.; Burd, C. E.; Croix, C. M. S.; Siuzdak, G.; Yates, N. A.; Robbins, P. D.; Wang, Y.; Wipf, P.; Kelley, E.; Niedernhofer, L. J. Redox Biol. 2018, 17, 259-73
“Combination of a Thioxodihydroquinazolinone with Cisplatin Eliminates Ovarian Cancer Stem Cell-Like Cells (CSC-LCs) and Shows Preclinical Potential,” Ma, J.; Van Houten, B.; Qian, W.; Ma, J.; Salamoun, J.; Wipf, P.; Edwards, R. Oncotarget 2018, 9, (5), 6042-6054
“Structure-Based Virtual Screening Identifies a Small-Molecule Inhibitor of the Profilin 1-Actin Interaction,” Gau, D.; Lewis, T.; McDermott, L.; Wipf, P.; Koes, D.; Roy, P. J. Biol. Chem. 2018, 293, (7), 2606-2616
“The GS-Nitroxide JP4-039 Improves Intestinal Barrier and Stem Cell Recovery in Irradiated Mice,” Wei, L.; Leibowitz, B. J.; Epperly, M.; Bi, C.; Li, A.; Steinman, J.; Wipf, P.; Li, S.; Zhang, L.; Greenberger, J.; Yu, J. Sci. Rep. 2018, 8, (1), 2072
“Evaluation of Mitochondrial Bioenergetics, Dynamics, Endoplasmic Reticulum-Mitochondria Crosstalk, and Reactive Oxygen Species in Fibroblasts from Patients with Complex I Deficiency,” Leipnitz, G.; Mohsen, A.-W.; Karunanidhi, A.; Seminotti, B.; Markantone, D. M.; Grings, M.; Mihalik, S. J.; Vockley, J.; Leipnitz, G.; Grings, M.; Roginskaya, V. Y.; Van Houten, B.; Wipf, P.; Vockley, J. Sci. Rep. 2018, 8, (1), 1165
“Liquid Chromatography-Tandem Mass Spectrometric Assay for the Quantitation of the Novel Radiation Protective Agent and Radiation Mitigator JP4-039 in Murine Plasma,” Christner, S.; Guo, J.; Parise, R. A.; Ringeval, M.; Hoye, A. T.; Wipf, P.; Epperly, M. W.; Greenberger, J. S.; Beumer, J. H.; Eiseman, J. L. J. Pharm. Biomed. Anal. 2018, 150, 169-175
“New Cav2 Calcium Channel Gating Modifiers with Agonist Activity and Therapeutic Potential to Treat Neuromuscular Disease,” Wu, M.; White, H. V.; Boehm, B.; Meriney, C. J.; Kerrigan, K.; Frasso, M.; Liang, M.; Gotway, E. M.; Wilcox, M.; Johnson, J. W.; Wipf, P.; Meriney, S. D. Neuropharmacol. 2018, 131, 176-189
“Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways,”  Steinman, J.; Epperly, M.; Hou, W.; Willis, J.; Wang, H.; Fisher, R.; Liu, B.; Bahar, I.; McCaw, T.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S.; Huq, M. S.; Greenberger, J. S.; Liu, B.; Bavar, I.; Kagan, V.; Bayir, H.; Yu, J.; Wipf, P.; Li, S. Rad. Res. 2018, 189, 68-83
“Lambert-Eaton Myasthenic Syndrome: Mouse Passive-Transfer Model Illuminates Disease Pathology and Facilitates Testing Therapeutic Leads,” Meriney, S. D.; Tarr, T, B.; Ojala, K. S.; Wu, M.; Li, Y.; Lacomis, D.; Garcia-Ocana, A.; Liang, M.; Valdomir, G. Ann. NY Acad. Sci. 2018, 1412, 73-81
“Small Molecule Targeting of PTPs in Cancer,” Lazo, J. S.; McQueeney, K. E.; Burnett, J. C.; Wipf, P.; Sharlow, E. R. Int. J. Biochem. Cell Biol. 2018, 96, 171-181
“t-BuOOH Induces Ferroptosis in Human and Murine Cell Lines,” Wenz, C.; Faust, D.; Linz, B.; Turmann, C.; Nikolova, T.; Bertin, J.; Gough, P.; Wipf, P.; Schröder, A. S.; Krautwald, S.; Dietrich, C. Arch. Toxicol. 2018, 92, (2), 759-775
“Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(Isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone,” Masoodi, K. Z.; Eisermann, K.; Yang, Z.; Dar, J. A.; Pascal, L. E.; Nguyen, M.; O'Malley, K.; Parrinello, E.; Feturi, F. G.; Kenefake, A. N.; Nelson, J. B.; Johnston, P. A.; Wipf, P.; Wang, Z. Endocrinol. 2017, 158, (10), 3152-3161
“N-Acetyl-L-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione,” Gleixner, A. M.; Hutchison, D. F.; Sannino, S.; Bhatia, T. N.; Leak, L. C.; Flaherty, P. T.; Wipf, P.; Brodsky, J. L.; Leak, R. K. Mol. Pharmacol. 2017, 92, (5), 564-575
“Inhibition of Androgen Receptor Nuclear Localization and Castration-Resistant Prostate Tumor Growth by Pyrroloimidazole-Based Small Molecules,” Masoodi, K. Z.; Xu, Y.; Dar, J. A.; Eisermann, K.; Pascal, L. E.; Parrinello, E.; Ai, J.; Johnston, P. A.; Nelson, J. B.; Wipf, P.; Wang, Z. Mol. Cancer Ther. 2017, 16, (10), 2120-2129
“Eight-Step Enantioselective Total Synthesis of (−)-Cycloclavine,” McCabe, S. R.; Wipf, P. Angew. Chem. Int. Ed. 2017, 56, (1), 324-327
“Mechanism of Action of Selective Inhibitors of IL-6 Induced STAT3 Pathway in Head and Neck Cancer Cell Lines,” Sen, M.; Pollock, N. I.; DeGrave, K.; Joyce, S. C.; Freilino, M. L.; Johnston, P. A.; Hua, Y.; Camarco, D. P.; Close, D. A.; Huryn, D. M.; Wipf, P.; Grandis, J. R. J. Chem. Biol. 2017, 10, 129-141
“Induction of TGF-b by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350,”  Epperly, M. W.; Rhieu, B.-H.; Franicola, D.; Dixon, T.; Cao, S.; Zhang, X.; Shields, D.; Wang, H.; Wipf, P.; Greenberger, J. S. In Vivo 2017, 31, 159-168
“Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells,” Tyurina, Y. Y.; Lou, W.; Qu, F.; Tyurin, V. A.; Mohammadyani, D.; Liu, J.; Huttemann, M.; Frasso, M. A.; Wipf, P.; Bayir, H.; Greenberger, M. L.; Kagan, V. E. ACS Chem. Biol. 2017, 12, 265-281
“A Structure-activity Relationship Study of ABCC2 Inhibitors,” Wissel, G.; Deng, F.; Kudryavtsev, P.; Ghemtio, L.; Wipf, P.; Xhaard, H.; Kidron, H. Eur. J. Pharm. Sci. 2017, 103, 60-69
“Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators,” Epperly, M. W.; Sacher, J. R.; Krainz, T.; Zhang, X.; Wipf, P.; Liang, M.; Fisher, R.; Li, S.; Wang, H.; Greenberger, J. S. In Vivo 2017, 31, 39-43
“ACS Medicinal Chemistry Letters: Technology Notes,” Wipf, P. ACS Med. Chem. Lett. 2017, 8, (1), 1-2
“A Topical Mitochondria-Targeted Redox-Cycling Nitroxide Mitigates Oxidative Stress-Induced Skin Damage,” Brand, R. M.; Epperly, M. W.; Stottlemyer, J. M.; Skoda, E. M.; Gao, X.; Li, S.; Huq, S.; Wipf, P.; Kagan, V. E.; Greenberger, J. S.; Falo, L. D. J. Invest. Derm. 2017, 137, 576-586
“Elucidating Mitochondrial ETC Supercomplexes in the Heart During Ischemia-Reperfusion,” Jang, S.; Lewis, T. S.; Powers, C.; Khuchua, Z.; Baines, C. P.; Wipf, P.; Javadov, S. Antioxid. Redox Signal. 2017, 27, (1), 57-69
“A Threonine Turnstile Defines a Dynamic Amphiphilic Binding Motif in the AAA ATPase p97 Allosteric Binding Site,” Burnett, J.; Lim, C.; Peyser, B. D.; Samankumara, L. P.; Kovaliov, M.; Colombo, R.; Bulfer, S.; LaPorte, M.; Hermone, A.; McGrath, C.; Arkin, M.; Gussio, R.; Huryn, D.; Wipf, P. Org. Biomol. Chem. 2017, 15, 4096-4114