Department of Chemistry

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Peter Wipf

Distinguished University Professor

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758 CHVRN
Chevron Science Center, 219 Parkman Avenue

Pittsburgh, PA 15260
412-624-8606

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Research Overview

Total Synthesis of Natural Products; Organometallic and Heterocyclic Chemistry; Medicinal Chemistry

Total Synthesis of Natural Products

Total Synthesis encompasses all aspects of organic chemistry: The development of new methodology, mechanistic and physical organic experiments, conformational and configurational analysis by spectroscopic and computational methods, and bioorganic and medicinal chemistry. Total Synthesis is also one of the broadest and most rewarding educational experiences for aspiring synthetic chemists.

Organometallic Chemistry

Organometallic Chemistry will provide most of new revolutionary techniques for C,C and C-heteroatom bond formations and asymmetric catalysis. Our group has had a long tradition in synthetic applications of transition metals.

Heterocyclic Chemistry

More than half of all known organic compounds, and the vast majority of drugs, are heterocyclic. We are interested in the development of new stereoselective methods for the preparation of highly functionalized heterocycles. In particular, we have developed novel protocols for five-membered heterocycle synthesis that have been widely adopted in industry and academe.

Combinatorial Synthesis & Medicinal Chemistry

We apply combinatorial chemistry and solid phase synthesis methods for reagent and catalyst design in organometallic and heterocyclic chemistry, and for the structure-activity analysis of bioactive natural products. Specifically, we are involved in collaborative drug discovery and development. Some of these projects take advantage of the infrastructure of the Combinatorial Chemistry Center (CCC).

 

Computational Prediction of Macroscopic Properties

In another exciting interdisciplinary collaboration, we have joined forces with the Beratan group for the computational assignment of the relative and absolute stereochemistry of organic molecules of organic molecules and the theoretical prediction of chiroptical phenomena.

 

 

 

 

Recent Advisory And Editorial Boards

  • Editorial Advisory Board, Helvetica Chimica Acta (2016-present)

  • ACS National Awards Selection Committee (2015)

  • Guest Editor for Israel Journal of Chemistry Special Issue on “Flow Chemistry”

  • Organic Syntheses, Inc., Board of Directors (2013-present)

  • Guest Editor for Molecules Special Issue on “Diversity Oriented Synthesis” (2011)

  • External Advisory Committee, Purdue University Center for Cancer Research, West Lafayette, IN (2010-present)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009)-present

  • Honorary Editorial Board, International Journal of High Throughput Screening (2009-present)

  • Organic Reactions, Inc., Board of Directors (2007-present)

  • International Advisory Editorial Board, Organic & Biomolecular Chemistry (2007-present)

Awards

  • Visiting Professor, RWTH Aachen, Aachen, Germany (2016)
  • Chair of the Section on Pharmaceutical Sciences of the American Association for the Advancement of Science (2016)
  • Provost's Award for Excellence in Mentoring (2015)
  • Humboldt Research Award of the Alexander von Humboldt Foundation (2014)
  • Harry and Carol Mosher Award of the Santa Clara Valley Section of the ACS (2013)
  • Edward W. Morley Award of the Cleveland Section of the ACS (2013)

  • ACS Pittsburgh Award (2012)

  • Fellow of the American Chemical Society (2010)

  • Ernest Guenther Award in the Chemistry of Natural Products (2009)

  • Associate Editor, ACS Medicinal Chemistry Letters (2009-present)

  • Organic Reactions, Inc. Board of Directors (2007-present)

  • Chancellor's Distinguished Research Award (2008)

  • Faculty of 1000 Biology (2006-present)

  • Novartis Chemistry Lectureship (2005)

  • Fellow of the Royal Society of Chemistry (FRSC, 2004)

  • Visiting Professor (Professeur Associé), École Supérieur de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI), Paris, France (September 2004)
  • Long Range Planning Committee, ACS Division of Medicinal Chemistry (2004-2006)
  • ISHC Katritzky Award in Heterocyclic Chemistry (2003)

  • Fellow of the American Association for the Advancement of Science (AAAS, 2002)
  • Chair, Gordon Research Conference on Stereochemistry, Salve Regina University, Newport, Rhode Island (June 9-14, 2002)
  • Visiting Professor (Professeur Associé), Université de Paris-Sud, Orsay, France (November 2001)
  • Member-at-Large, Organic Division Executive Committee of the ACS (2001-2003)
  • Novartis Research Award (2000, 2001)
  • Japan Society for the Promotion of Science Fellow (2000)

  • Akron Section ACS Award (1998)

  • Arthur C. Cope Scholar Award (1998)

  • NIH Medicinal Chemistry Study Section, Member, 1998-2003, Chairman, 2001-2003

  • Chancellorís Distinguished Research Award (1997)

  • Phi Eta Sigma, Honorary Member (1996)

  • Merck Young Investigator Award (1995)

  • Zeneca Award for Excellence in Chemistry (1995)

  • Camille Dreyfus Teacher-Scholar Award (1995)

  • UCI-Allergan Visiting Lecturer, University of California, Irvine, California (May, 1995)
  • NSF Presidential Faculty Fellow (1994-1999)

  • ETH Ruzicka Award (1994)

  • Alfred P. Sloan Research Fellow (1994-1996)

  • American Cyanamid Faculty Award (1994)

  • Eli Lilly Grantee (1993-1995)

  • University of Zürich, Distinguished Dissertation Award (1987)


Publications

“Eight-Step Enantioselective Total Synthesis of (−)-Cycloclavine,” McCabe, S. R.; Wipf, P. , Angew. Chem. Int. Ed., Vol. 56, 2017, Pages (1), 324-327
“Dihydropyrimidinones and -Thiones With Improved Activity Against Human Polyomavirus Family Members,” Manos-Turvey, A.; Al-Ashtal, H. A.; Needham, P. G.; Hartline, C. B.; Prichard, M. N.; Wipf, P.; Brodsky, J. L. , Bioorg. Med. Chem. Lett., Vol. 26, 2016, Pages 5087-5091
“Elucidating Mitochondrial ETC Supercomplexes in the Heart During Ischemia-Reperfusion,”  Jang, S.; Lewis Taber, S.; Wipf, P.; Powers, C.; Khuchua, Z.; Baines Christopher, P.; Javadov, S. , Antioxid. Redox Signal., 2016, Pages in press
“A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis,” Krainz, T.; Gaschler, M. M.; Lim, C.; Sacher, J. R.; Stockwell, B. R.; Wipf, P. , ACS Cent. Sci., Vol. 2, 2016, Pages (9), 653-659
“Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles,” Milligan, J. A.; Busacca, C. A.; Senanayake, C. H.; Wipf, P. , Org. Lett., Vol. 18, 2016, Pages (17), 4300-4303
“Allosteric Modulation of Phosphatase Activity May Redefine Therapeutic Value,” Salamoun, J. M.; Wipf, P. , J. Med. Chem., Vol. 59, 2016, Pages (17), 7771-7772
“Combined Chemical-Genetic Approach Identifies Cytosolic HSP70 Dependence in Rhabdomyosarcoma,” Sabnis, A. J.; Guerriero, C. J.; Olivas, V.; Sayana, A.; Shue, J.; Flanagan, J.; Asthana, S.; Paton, A. W.; Paton, J. C.; Gestwicki, J. E.; Walter, P.; Weissman, J. S.; Wipf, P.; Brodsky, J. L.; Bivona, T. G. , Proc. Natl. Acad. Sci. USA, Vol. 113, 2016, Pages (32), 9015-9020
“Total Synthesis and Biological Evaluation of Tubulysin Analogues,” Colombo, R.; Wang, Z.; Han, J.; Balachandran, R.; Daghestani, H. N.; Camarco, D. P.; Vogt, A.; Day, B. W.; Mendel, D.; Wipf, P. , J. Org. Chem., Vol. 81, 2016, Pages (21), 10302-10320
“Optimization of Pyrazole-Containing 1,2,4-Triazolo-[3,4-B]Thiadiazines, a New Class of STAT3 Pathway Inhibitors,” Laporte, M. G.; Wang, Z.; Colombo, R.; Garzan, A.; Peshkov, V. A.; Liang, M.; Johnston, P. A.; Schurdak, M. E.; Sen, M.; Camarco, D. P.; Hua, Y.; Pollock, N. I.; Lazo, J. S.; Grandis, J. R.; Wipf, P.; Huryn, D. M. , Bioorg. Med. Chem. Lett., Vol. 26, 2016, Pages 3581-3585
“Photooxygenation of an Amino-Thienopyridone Yields a More Potent PTP4A3 Inhibitor,” Salamoun, J. M.; McQueeney, K. E.; Patil, K.; Geib, S. J.; Sharlow, E. R.; Lazo, J. S.; Wipf, P. , Org. Biomol. Chem., Vol. 14, 2016, Pages 6398-6402
“Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer ,” Johnson, J. K.; Skoda, E. M.; Zhou, J.; Parrinello, E.; Wang, D.; O'Malley, K.; Eyer, B. R.; Kazancioglu, M. Z.; Eisermann, K.; Johnston, P. A.; Nelson, J. B.; Wang, Z.; Wipf, P. , ACS Med. Chem. Lett. , Vol. 7, 2016, Pages (8), 785-790
“Total Synthesis, Biosynthesis and Biological Profiles of Clavine Alkaloids,” McCabe, S. R.; Wipf, P. , Org. Biomol. Chem., Vol. 14, 2016, Pages 5894-5913
“Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells,” Johnston, P. A.; Nguyen, M. M.; Dar, J. A.; Ai, J.; Wang, Y.; Masoodi, K. Z.; Shun, T.; Shinde, S.; Camarco, D. P.; Hua, Y.; Huryn, D. M.; Wilson, G. M.; Lazo, J. S.; Nelson, J. B.; Wipf, P.; Wang, Z. , Assay Drug Dev. Technol., Vol. 14, 2016, Pages 226-239
“Mitochondrial Targeting of XJB-5-131 Attenuates or Improves Pathophysiology in HdhQ150 Animals with Well-Developed Disease Phenotypes,” Polyzos, A.; Holt, A.; Brown, C.; Cosme, C.; Wipf, P.; Gomez-Marin, A.; Castro, M. R.; Ayala-Peña, S.; McMurray, C. T. , Hum. Mol. Gen., Vol. 25, 2016, Pages (9), 1792-1802
“Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators,” Kumar, M.; Reed, N.; Liu, R.; Aizenmann, E.; Wipf, P.; Tzounopoulos, T. , Mol. Pharmacol., Vol. 89, 2016, Pages (6), 667-677
“Click Chemistry: Straining to React,” Milligan, J. A.; Wipf, P. , Nat. Chem., Vol. 8, 2016, Pages 296-297
“Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice,” Shinde, A.; Berhane, H.; Rhieu, B. H.; Kalash, R.; Xu, K.; Goff, J.; Epperly, M. W.; Franicola, D.; Zhang, X.; Dixon, T.; Shields, D.; Wang, H.; Greenberger, J. S.; Wipf, P.; Parmar, K.; Guinan, E.; Kagan, V.; Tyurin, V.; Ferris, R. L.; Zhang, X.; Li, S. , Radiat. Res., Vol. 185, 2016, Pages 134-150
“Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 Map Kinase Inhibitor,” Wilson, B. a. P.; Guszczynski, T.; Mitchell, C. A.; Alam, M. S.; Ashwell, J. D.; Jakob, M.; Shenoy, S. R.; Goncharova, E. I.; Evans, J. R.; Wipf, P.; Liu, G.; O'Keefe, B. R. , J. Biomol. Screen. , Vol. 21, 2016, Pages 277-289
“2.3 Å Resolution Cryo-EM Structure of Human p97 and Mechanism of Allosteric Inhibition,” Banerjee, S.; Bartesaghi, A.; Merk, A.; Rao, P.; Bulfer, S. L.; Yan, Y.; Green, N.; Mroczkowski, B.; Neitz, R. J.; Wipf, P.; Falconieri, V.; Deshaies, R. J.; Milne, J. L. S.; Huryn, D.; Arkin, M.; Subramaniam, S. , Science , Vol. 351, 2016, Pages (6275), 871-875.
“Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway,”  Alverez, C.; Bulfer, S. L.; Chakrasali, R.; Chimenti, M. S.; Deshaies, R. J.; Green, N.; Kelly, M.; Laporte, M. G.; Lewis, T. S.; Liang, M.; Moore, W. J.; Neitz, R. J.; Peshkov, V. A.; Walters, M. A.; Zhang, F.; Arkin, M. R.; Wipf, P.; Huryn, D. M. , ACS Med. Chem. Lett. , Vol. 7, 2016, Pages 182-187
“Gene Therapy for Mucositis,” Greenberger, J. S.; Epperly, M. W.; Wipf, P.; Li, S.; Kagan, V.; Gao, X. , In Genomics, Personalized Medicine and Oral Disease; Sonis, S. T., Ed.; Springer International Publishing Switzerland, 2015, Pages 345-362
“Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97,” Alverez, C.; Arkin, M. R.; Bulfer, S. L.; Colombo, R.; Kovaliov, M.; Laporte, M. G.; Lim, C.; Liang, M.; Moore, W. J.; Neitz, R. J.; Yan, Y.; Yue, Z.; Huryn, D. M.; Wipf, P.  , ACS Med. Chem. Lett., Vol. 6, 2015, Pages 1225-1230
“Bis-Cyclopropane Analog of Disorazole C1 is a Microtubule-Destabilizing Agent Active in ABCB1-Overexpressing Human Colon Cancer Cells,” Wu, S.; Guo, Z.; Hopkins, C. D.; Wei, N.; Chu, E.; Wipf, P.; Schmitz, J. C. , Oncotarget, Vol. 6, 2015, Pages 40866-40879
“Mitochondria-Targeted Antioxidant Preserves Contractile Properties and Mitochondrial Function of Skeletal Muscle in Aged Rats,” Javadov, S.; Jang, S.; Rodriguez-Reyes, N.; Rodriguez-Zayas A. E.; Soto Hernandez, J.; Frontera, W.; Krainz, T.; Wipf, P.; Frontera, W. , Oncotarget, Vol. 6, 2015, Pages 39469-39481
“Cascade Cyclization Triggered by Imine Formation. Formal Synthesis of the Alkaloid (±)-Stemoamide and its 9a-Epimer,” Brito, G. A.; Sarotti, A. M.; Wipf, P.; Pilli, R. A. , Tetrahedron Lett., Vol. 56, 2015, Pages 6664-6668
“Mitochondrial Targeted β-Lapachone Induces Mitochondrial Dysfunction and Catastrophic Vacuolization in Cancer Cells,” Ma, J.; Lim, C.; Sacher, J. R.; Van Houten, B.; Qian, W.; Wipf, P. , Bioorg. Med. Chem. Lett. , Vol. 25, 2015, Pages 4828-4833
“One-pot Hydrozirconation/Copper‐catalyzed Conjugate Addition of Alkylzirconocenes to Enones,” Arnold, D.; Krainz, T.; Wipf, P. , Org. Synth., Vol. 92, 2015, Pages 277-295
“HCS Campaign to Identify Selective Inhibitors of IL-6-Induced Stat3 Pathway Activation in Head and Neck Cancer Cell Lines,” Johnston, P. A.; Sen, M.; Hua, Y.; Camarco, D. P.; Shun, T. Y.; Lazo, J. S.; Wilson, G. M.; Resnick, L. O.; La Porte, M. G.; Wipf, P.; Huryn, D. M.; Grandis, J. R. , Assay Drug Dev. Technol., Vol. 13, 2015, Pages 356-376
“Conformational Restriction and Steric Hindrance in Medicinal Chemistry,” Wipf, P.; Skoda, E. M.; Mann, A. , In The Practice of Medicinal Chemistry, 4th ed.; Wermuth, C. G., Aldous, D., Raboisson, P., Rognan, D., Ed.; Academic Press: Burlington, MA, Chapter 11, 2015, Pages 279-301
“Exploring the Structure-Activity Relationships of ABCC2 Modulators using a Screening Approach,” Wissel, G.; Kudryavtsev, P.; Ghemtio, L.; Tammela, P.; Yliperttula, M.; Wipf, P.; Finel, M.; Urtti, A.; Kidron, H.; Xhaard, H. , Bioorg. Med. Chem., Vol. 23, 2015, Pages 3513-3525
“Heat Shock Protein Responses to Aging and Proteotoxicity in the Olfactory Bulb,” Crum, T. S.; Gleixner, A. M.; Posimo, J. M.; Mason, D. M.; Broeren, M. T.; Heinemann, S. D.; Wipf, P.; Brodsky, J. L.; Leak, R. K. , J. Neurochem., Vol. 133, 2015, Pages 780-794
“Heat Shock Protein Defenses in the Neocortex and Allocortex of the Telencephalon,”  Posimo, J. M.; Weilnau, J. N.; Gleixner, A. M.; Broeren, M. T.; Weiland, N. L.; Brodsky, J. L.; Wipf, P.; Leak, R. K. , Neurobiol. Aging , Vol. 36, 2015, Pages 1924-1937
“Ring-Strain-Enabled Reaction Discovery: New Heterocycles from Bicyclo[1.1.0]butanes,” Walczak, M. A. A.; Krainz, T.; Wipf, P. , Acc. Chem. Res., Vol. 48, 2015, Pages 1149-1158
“The Cytotoxic Effects of Regorafenib in Combination with Protein Kinase D Inhibition in Human Colorectal Cancer Cells,” Wei, N.; Chu, E.; Wu, S.-Y.; Wipf, P.; Schmitz J. C. , Oncotarget, Vol. 6, 2015, Pages 4745-4756
“Synthesis and Biological Evaluation of 3-Aminoisoquinoline-1(2H)-one Based Inhibitors of the Dual-Specificity Phosphatase Cdc25B,” Rosenker, K. M. G.; Paquette, W. D.; Johnston, P. A.; Sharlow, E. R.; Vogt, A.; Bakan, A.; Lazo, J. S.; Wipf, P. , Biorg. Med. Chem. Lett., Vol. 23, 2015, Pages 2810-2818
“SD-208, a Novel Protein Kinase D Inhibitor, Blocks Prostate Cancer Cell Proliferation and Tumor Growth in Vivo by Inducing G2/M Cell Cycle Arrest,” Tandon, M.; Carder E. J.; Xu, S.; Wang, Q. J.; Salamoun J., M.; Farber, E.; Wipf, P.; Deng, F.; Tang, H. , PLoS One , Vol. 10, 2015, Pages e0119346
“The Combination of Thioxodihydroquinazolinones and Platinum Drugs Reverses Platinum Resistance in Tumor Cells by Inducing Mitochondrial Apoptosis Independent of Bax and Bak,” Qian, W.; Salamoun, J.; Wang, J.; Roginskaya, V.; Van Houten, B.; Wipf, P. , Bioorg. Med. Chem. Lett., Vol. 25, 2015, Pages 856-863
“Antioxidant Approaches to Management of Ionizing Irradiation Injury,” Greenberger, J.; Kagan, V.; Bayir, H.; Wipf, P.; Epperly, M. , Antioxidants , Vol. 4, 2015, Pages (1), 82-101
“ Synthesis of Anti-inflammatory α-and β-Linked Acetamidopyranosides as Inhibitors of Toll-like Receptor 4 (TLR4),” Wipf, P.; Eyer, B. R.; Yamaguchi, Y.; Zhang, F.; Neal, M. D.; Sodhi, C. P.; Good, M.; Branca, M.; Prindle Jr, T.; Lu, P.; Brodsky, J. L.; Hackam, D. J. , Tetrahedron Lett., Vol. 56, 2015, Pages 3097-3100
“Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome,” Tarr, T.; Wipf, P.; Meriney, S. , Mol. Neurobiol. , Vol. 52, 2015, Pages (1), 456-463
“Deciphering of Mitochondrial Cardiolipin Oxidative Signaling in Cerebral Ischemia-Reperfusion,” Ji, J.; Baart, S.; Vikulina, A. S.; Clark, R. S. B.; Anthonymuthu, T. S.; Tyurin, V. A.; Du, L.; St Croix, C. M.; Tyurina, Y. Y.; Lewis, J.; Skoda, E. M.; Kline, A. E.; Kochanek, P. M.; Wipf, P.; Kagan, V. E.; Bayir, H. , J. Cereb. Blood Flow Metab., Vol. 35, 2015, Pages 319-328
“[2,3]-Sigmatropic Rearrangements of 2-Phosphineborane 2-Propen-1-ols: Rapid Access to Enantioenriched Diphosphine Monoxide Derivatives,” Busacca, C. A.; Qu, B.; Farber, E.; Haddad, N.; Gret, N.; Saha, A. K.; Eriksson, M. C.; Wu, J.-P.; Fandrick, K. R.; Han, S.; Grinberg, N.; Ma, S.; Lee, H.; Li, Z.; Spinelli, M.; Gold, A.; Wang, Z.; Wang, G.; Wipf, P.; Senanayake, C.H., Org. Lett., Vol. 15, 2013, Pages (5),1136-1139
“Hydrophosphination of Propargylic Alcohols and Amines with Phosphine Boranes,” Busacca, C. A.; Qu, B.; Farber, E.; Haddad, N.;Gret, N.; Saha, A. K.; Eriksson, M. C.; Wu, J.-P.; Fandrick, K. R.; Has, S.; Grinber, N.; Ma, S.; Lee, H.; Li, Z.; Spinelli, M.; Gold, A.; Wang, G.; Wipf, P.; Senanayake, C.H., Org. Lett, Vol. 15, 2013, Pages (5), 1132-1135
“Influence of Base and Structure in the Reversible Covalent Conjugate Addition of Thiol to Polycyclic Enone Scaffolds,” Rosenker, C. J.; Krenske, E. H.; Houk, K. N.; Wipf, P., Org. Lett., Vol. 15, 2013, Pages (5), 1076-1079
“Mitochondrial-derived Reactive Oxygen Species (ROS) Play a Causal Role in Aging-related Intervertebral Disc Degeneration,” Nasto, L. A.; Robinson, A.; Ngo, K.; Clausen, C. L.; Dong, Q.; St. Croix, C.; Sowa, G.; Pola, E.; Robbins, P. D.; Kang, J.; Niedernhofer, L. J.; Wipf, P.; Vo, M. V., J. Orthopaed. Res., 2013,
“Cycloadditions in Heterocycle and Alkaloid Synthesis,” Wipf, P.; Fang, Z.; Ferrié, L.; Ueda, M.; Walczak, M. A. A.; Yan, Y.; Yang, M., Pure Appl. Chem., Vol. 85, 2013,
“Nanoassembly of Surfactants with Interfacial Drug-Interactive Motifs as Tailor-Designed Drug Carriers,” Gao, X.; Huang, Y.; Makhov, A. M.; Epperly, M.; Lu, J.; Grab, S.; Zhang, P.; Rohan, L.; Xie, X.-Q.; Wipf, P.; Greenberger, J.; Li, S., S. Mol. Pharm., Vol. 10, 2013, Pages 187-198
“In Vitro Cytotoxicity, Pharmacokinetics, Tissue Distribution, and Metabolism of Small-Molecule Protein Kinase D Inhibitors, kb-nb142-70 and kb-nb165-09, in Mice Bearing Human Cancer Xenografts,” Guo, J.; Clausen D. M.; Beumer J. H.; Parise R. A.; Egorin M. J.; Bravo-Altamirano, K.; Wipf, P.; Sharlow E. R.; Wang Q. J.; Eiseman J. L., Cancer Chemother. Pharmacol, Vol. 71, 2013, Pages (2), 331-344
“New Calcium Channel Agonists as Potential Therapeutics in Lambert-Eaton Myasthenic Syndrome and other Neuromuscular Diseases,” Tarr, T. B.; Valdomir, G.; Liang, M.; Wipf, P.; Meriney, S. D., Ann. N. Y. Acad. Sci., Vol. 1275, 2012, Pages (1), 85-91
“Synthesis and Biological Evaluation of a Selective N- and P/Q-Type Calcium Channel Agonist,” Liang, M.; Tarr, T. B.; Bravo-Altamirano, K.; Valdomir, G.; Rensch, G.; Swanson, L.; DeStefino, N. R.; Mazzarisi, C. M.; Olszewski, R. A.; Wilson, G. M.; Meriney, S. D.; Wipf, P., ACS Me. Chem. Lett., Vol. 3, 2012, Pages (12), 985-990
“A Targeted Library Screen Reveals a New Inhibitor Scaffold for Protein Kinase D,” Tandon, M.; Wang, L.; Xu, Q.; Xie, X.; Wipf, P.; Wang, Q. J., PLoS One, Vol. 7, 2012, Pages (9), e44653
“Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington’s Disease,” Xun, Z.; Rivera-Sanchez, S.; Ayala-Penã, S.; Lim, J.; Budworth, H.; Skoda, E. M.; Robbins, P. D.; Niedernhofer, L. J.; Wipf, P.; McMurray, C. T., Cell Rep., Vol. 2, 2012, Pages (5), 1137-1142
“Global Lipidomics Identifies Cardiolipin Oxidation as a Mitochondrial Target for Redox Therapy of Acute Brain Injury,” Ji, J.; Kline, A. E.; Amoscato, A.; Arias, A. S.; Sparvero, L. J.; Tyurin, V. A.; Tyrina, Y. Y.; Fink, B.; Cheng, J. P.; Alexander, H.; Clark, R. S. B.; Kochanek, P. M.; Wipf, P.; Kagan, V. E.; Bayir, H., Nat. Neurosci., Vol. 15, 2012, Pages (10), 1407-1413
“Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways,” Mccarthy, J. G.; Eisman, E. B.; Kulkarni, S.; Gerwick, L.; Gerwick, W. H.; Wipf, P.; Sherman, D. H.; Smith, J. L., ACS Chem. Biol., Vol. 7, 2012, Pages (12), 1994-2003
“Lipophilicity Screening of Novel Drug-Like Compounds and Comparison to cLog P,” Lu, D.; Chambers, P.; Wipf, P.; Xie, X.-Q.; Englert, D.; Weber, S., J. Chromatogr. A, Vol. 1258, 2012, Pages 161-167
“Synthesis of a Library of Tricyclic Azepinoisoindolinones,” Miller, B.; Mao, S.; Rosenker, K. M. G.; Pierce, J. G.; Wipf, P., Beilstein J. Org. Chem. (Special Issue on Recent Developments in Chemical Diversity), Vol. 8, 2012, Pages 1091-1097
“A Screen for Modulators of Large T Antigen’s ATPase Activity Uncovers Novel Inhibitors of Simian Virus 40 and BK Virus Replication,” Seguin, S. P.; Ireland, A. W.; Miyata, Y.; Wipf, P.; Pipas, J. M.; Gestwicki, J. E.; Brodsky, J. L., Antivir. Res., Vol. 96, 2012, Pages 70-81
“Geographic Variability and Anti-Staphylococcal Activity of the Chrysophaentins and Their Synthetic Fragments,” Keffer, J. L.; Hammill, J. T.; Lloyd, J. R.; Plaza, A.; Wipf, P.; Bewley, C. A., Mar. Drugs, Vol. 10, 2012, Pages (5), 1103-1125
“A Bifunctional Dimethylsulfoxide Substitute Enhances the Aqueous Solubility of Small Organic Molecules,” Sprachman, M. M.; Wipf, P., ASSAY Drug Dev. Technol., Vol. 10, 2012, Pages (3), 269-277
“Strategies for Discovery of Small Molecule Radiation Protectors and Radiation Mitigators,” Greenberger, J. S.; Clump, D.; Kagan, V.; Bayir, H.; Lazo, J. S.; Wipf, P.; Li, S.; Gao, X.; Epperly, M. W., Front. Oncol., Vol. 1, 2012, Pages Article 59, 1-12
“Synthesis of 1,2,4-Triazines and the Triazinoisoquinolinedione DEF Ring System of Noelaquinone,” Cao, L.; Maciejewski, J. P.; Elzner, S.; Amantini, D.; Wipf, P., Org. Biomol. Chem. (Special 10 Year Anniversary Issue), Vol. 10, 2012, Pages 5811-5814
“Selenosemicarbazones as Potent Cruzipain Inhibitors and Their Antiparasitic Properties against Trypanosoma cruzi,” Pizzo, C.; Faral-Tello, P.; Salinas, G.; Flo, M.; Robello, C.; Wipf, P.; Mahler, S. G., MedChemComm, Vol. 3, 2012, Pages 362-368
“Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres,” Skoda, E. M.; Davis, G. C.; Wipf, P., Org. Proc. Res. Dev., Vol. 16, 2012, Pages (1), 26-34
“Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1a Ligand Functionality,” Wang, L.; Ma, C.; Wipf, P.; Xie, X.-Q., Mol. Informatics, Vol. 31, 2012, Pages 85-95
“Genetically Encoded Redox Sensor Identifies the Role of ROS in Degenerative and Mitochondrial Disease Pathogenesis,” Liu, Z.; Celotto, A. M.; Romero, G.; Wipf, P.; Palladino, M. J., Neurobiol. Dis., Vol. 45, 2012, Pages (1), 362-368
“Structure-Activity Relationships amongst 4-Position Quinoline Methanol Antimalarials that Inhibit the Growth of Drug Sensitive and Resistant Strains of Plasmodium Falciparum.,” Milner, E.; McCalmont, W.; Bhonsle, J.; Caridha, D.; Carroll, D. W.; Gardner, S.; Gerena, L.; Gettayacamin, M.; Lanteri, C.; Luong, T.; Melendez, V.; Moon, J. K.; Roncal, N. E.; Sousa, J. C.; Tangteung, A.; Wipf, P.; Dow, G. S., Bioorg. Med. Chem. Lett., Vol. 20, 2010, Pages (4), 1347-1351
“Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline.,” Wipf, P.; George, K. M. , Synlett (Special Issue Honoring G. Pattenden), 2010, Pages 644-648
“Screening of Antimicrobial Agents for In Vitro Radiation Protection and Mitigation Capacity, Including those Used in Supportive Care Regimens for Bone Marrow Transplant Recipients.,” Epperly, M. W.; Franicola, D.; Shields, D.; Rwigema, J.-C.; Zhang, X.; McBride, W.; Georges, G.; Wipf, P.; Greenberger, J. S., In Vivo, Vol. 24, 2010, Pages (1), 9-19
“Transmetalation Reactions Producing Organocopper Compounds.,” Rosenker, C. J.; Wipf, P. In “Patai Series: The Chemistry of Functional Groups. The Chemistry of Organocopper Compounds”, Rappoport, Z.; Marek, I., Eds., Wiley Interscience, 2010, Pages Part 1, Chapter 10, pp 443-525
“Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents,” Wipf, P.; Xiao, J.; Stephenson, C. R. J., Chimia, Vol. 63, 2009, Pages 764-775
“Phosphatases as Targets for Cancer Treatment,” Lazo, J. S.; Wipf, P., Curr. Op. Invest. Drugs, Vol. 10, 2009, Pages 1297-1304
“Mitochondrial Targeting of Electron Scavenging Antioxidants: Regulation of Selective Oxidation vs Random Chain Reactions,” Kagan, V. E.; Wipf, P.; Stoyanovsky, D.; Greenberger, J. S.; Borisenko, G.; Belikova, N. A.; Yanamala, N.; Samhan Arias, A. K.; Tungekar, M. A.; Jiang, J.; Tyurina, Y. Y.; Ji, J.; Klein-Seetharaman, J.; Pitt, B. R.; Shvedova, A. A.; Bayir, H., Adv. Drug Deliv. Rev, Vol. 61, 2009, Pages 1375-1385
“The Mitochondria-Targeted Nitroxide JP4-039 Augments Potentially Lethal Irradiation Damage Repair,” Rajagopalan, M. S.; Gupta, K.; Epperly, M. W.; Franicola, D.; Zhang, X.; Wang, H.; Zhao, H.; Tyurin, V. A.; Pierce, J. G.; Kagan, V. E.; Wipf, P.; Kanai, A. J.; Greenberger, J. S., In Vivo, Vol. 23, 2009, Pages 717-726
“Synthesis of Pyrrolo[1,3]diazepines by a Dipolar Cycloaddition – retro-Mannich Domino Reaction,” Liang, M.; Saiz, C.; Pizzo, C.; Wipf, P., Tetrahedron Lett., Vol. 50, 2009, Pages 6810-6813
“Reversible Thiazolidine Exchange: A New Reaction Suitable for Dynamic Combinatorial Chemistry,” Saiz, C.; Wipf, P.; Manta, E.; Mahler, G., Org. Lett., Vol. 11, 2009, Pages 3170-3173
“Synthesis and Biological Evaluation of the First Pentafluorosulfanyl Analogs of Mefloquine,” Wipf, P.; Mo, T.; Geib, S. J.; Caridha, D.; Dow, G. S.; Gerena, L.; Roncal, N.; Milner, E. E., Org. Biomol. Chem., Vol. 7, 2009, Pages 4163-4165
“Evaluating b-Turn Mimics as b-Sheet Folding Nucleators,” Fuller, A. A.; Du, D.; Liu, F.; Davoren, J. E.; Bhabha, G.; Kroon, G.; Case, D. A.; Dyson, H. J.; Powers, E. T.; Wipf, P.; Gruebele, M.; Kelly, J. W., Proc. Natl. Acad. Sci. USA, Vol. 106, 2009, Pages 11067-11072
“Optical Signatures of Molecular Dissymmetry: Combining Theory with Experiments to Address Stereochemical Puzzles,” Mukhopadhyay, P.; Wipf, P.; Beratan, D. N., Acc. Chem. Res., Vol. 42, 2009, Pages 809-819
“Metamorphic Enzyme Assembly in Polyketide Diversification,” Gu, L.; Wang, B.; Kulkarni, A.; Geders, T. W.; Grindberg, R. V.; Gerwick, L.; Hakansson, K.; Wipf, P.; Smith, J. L.; Gerwick, W. H.; Sherman, D. H., Nature, Vol. 459, 2009, Pages 731-735
“Nanoparticles in Cellular Drug Delivery,” Faraji, A. H.; Wipf, P., Bioorg. Med. Chem., Vol. 17, 2009, Pages 2950-2962
“Cytochrome C/Cardiolipin Relations in Mitochondria: a Kiss of Death,” Kagan, V. E.; Bayir, H.; Belikova, N. A.; Kapralov, A.; Tyurina, Y. Y.; Tyurin, V. A.; Jiang, J.; Stoyanovsky, D.; Wipf, P.; Kochanek, P. M.; Borisenko, G. G.; Greenberger, J. S.; Shvedova, A. A.; Borisenko, G., G. Mol. Free Rad. Biol. Med., Vol. 46, 2009, Pages 1439-1453
“Isolation, Biology and Chemistry of the Disorazoles: New Anti-Cancer Macrodiolides,” Hopkins, C. D.; Wipf, P., Nat. Prod. Rep., Vol. 26, 2009, Pages 585-601
“Select Pyrimidinones Inhibit the Propagation of the Malarial Parasite, Plasmodium Falciparum,” Chiang, A. N.; Valderramos, J.-C.; Balachandran, R.; Chovatiya, R. J.; Mead, B. P.; Schneider, C. X; Bell, S. L.; Klein, M. G.; Huryn, D. M.; Chen, X. S.; Day, B. W.; Fidock, D. A.; Wipf, P.; Brodsky, J. L., Bioorg. Med. Chem., Vol. 17, 2009, Pages 1527-1533
“Synthesis and Biological Evaluation of Inhibitors of Botulinum Neurotoxin Metalloprotease,” Wang, C.; Widom, J.; Petronijevic, F.; Burnett, J. C.; Nuss, J. E.; Bavari, S.; Gussio, R.; Wipf, P., Heterocycles (Special Issue Honoring J. Daly), Vol. 79, 2009, Pages 487-520
“A Microwave Assisted Intramolecular-Furan-Diels-Alder Approach to 4-Substituted Indoles,” Petronijevic, F.; Timmons, C.; Cuzzupe, A.; Wipf, P., Chem. Commun., Vol. 1, 2009, Pages 104-106
“Triple Hybrids of Steroids, Spiroketals, and Oligopeptides as New Biomolecular Chimeras,” Banerjee, A.; Sergienko, E.; Vasile, S.; Gupta, V.; Vuori, K.; Wipf, P., Org. Lett., Vol. 11, 2009, Pages 65-68
“Formal Alder-Ene Reaction of a Bicyclo[1.1.0]butane in the Synthesis of the Tricyclic Quaternary Ammonium Core of Daphniglaucin,” Ueda, M.; Walczak, M. A. A.; Wipf, P., Tetrahedron Lett., Vol. 49, 2008, Pages 5986-5989
“Rhodium(I)-Catalyzed Cycloisomerizations of Bicyclobutanes,” Walczak, M. A. A.; Wipf, P., J. Am. Chem. Soc., Vol. 130, 2008, Pages 6924-6925
“Targeting Mitochondria,” Hoye, A. T.; Davoren, J.; Wipf, P.; Fink, M. P.; Kagan, V. E., Acc. Chem. Res., Vol. 41, 2008, Pages 87-97