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Computational Biophysics; Biomolecular simulations
Research in the Chong lab involves the development and application of molecular simulation approaches to model a variety of biophysical processes. A summary of some of our research directions is provided below.
Weighted ensemble approaches for sampling rare events
To enable the efficient simulation of rare events (e.g. protein folding and binding processes), we have been developing approaches based on “weighted ensemble” path sampling, which introduces no bias into the dynamics. Using our high-performance implementation of this approach (WESTPA), we and others have demonstrated that this approach can enhance the efficiency of generating pathways and rate constants for rare events by orders of magnitude
Simulation of protein binding pathways and kinetics
Obtaining atomically detailed views of protein binding (and unbinding) processes has been a grand challenge in the field of biomolecular simulation due to the long timescales required. To tackle this difficult problem, we have been using weighted ensemble algorithms to generate pathways and rate constants for various protein binding processes, including those that involve intrinsically disordered peptides that fold only upon binding their intended partner proteins.
Design of protein conformational switches
The process of designing protein conformational switches involves a significant amount of educated guesswork in the laboratory. To aid in the rational design of protein switches, we have been developing simulation approaches with various levels of coarse-graining to efficiently predict the dynamics of these protein switches. We have been focusing on a particular class of protein-based switches that are engineered using a "mutually exclusive folding" strategy in which two formerly independent protein domains are fused together in such a way that at any moment in time, only one or the other protein can be folded, but not both.
- National Science Foundation CAREER Award, 2009-2014
- Carnegie Science Emerging Female Scientist Award, 2012
- Hewlett-Packard Outstanding Junior Faculty Award, 2008
- Frank M. Goyan Graduate Research Award in Physical Chemistry at UCSF, 2002
- Burroughs Wellcome Graduate Research Fellowship, 2001-2002
- National Science Foundation Graduate Research Fellowship, 1998-2001