Title: Chemical-proteomic strategies to investigate reactive cysteines.
Abstract: Cysteine residues are critical to maintaining specialized protein functions, including nucleophilic catalysis, redox regulation, and metal binding. Research in the Weerapana Lab focuses on developing chemoproteomic platforms to identify functional cysteines and generate covalent ligands to regulate diverse cysteine-mediated protein functions. Specifically, our platforms have led to the identification of new functional cysteine residues involved in metal binding, redox regulation through oxidation and nitrosation, and electrophilic modification by reactive endogenous metabolites. Together, our studies aim to expand the toolkit of methods available to interrogate cysteine function and regulation within different cellular environments, whilst providing important insights into regulatory pathways active in diverse (patho)physiological systems.
See more of Dr. Weerapana's research on her website: https://sites.bc.edu/eranthie-weerapana/
Location and Address
Chevron 150